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Gastroenterology Research and Practice
Volume 2012 (2012), Article ID 247309, 10 pages
Differentiating Branch Duct and Mixed IPMN in Endoscopically Collected Pancreatic Cyst Fluid via Cytokine Analysis
1Center for Pancreatic Disease and Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital and Department of Medicine, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
2Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
3Department of Radiology, Brigham and Women’s Hospital, Boston, MA 02115, USA
4Department of Pathology, Boston’s Children Hospital, Boston, MA 02115, USA
5Proteomics Center, Boston’s Children Hospital, Boston, MA 02115, USA
Received 1 October 2012; Revised 31 October 2012; Accepted 14 November 2012
Academic Editor: Massimo Raimondo
Copyright © 2012 Linda S. Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- L. S. Lee, J. R. Saltzman, B. C. Bounds, J. M. Poneros, W. R. Brugge, and C. C. Thompson, “EUS-guided fine needle aspiration of pancreatic cysts: a retrospective analysis of complications and their predictors,” Clinical Gastroenterology and Hepatology, vol. 3, no. 3, pp. 231–236, 2005.
- H. Al Haddad, P. B. Laursen, D. Chollet, S. Ahmaidi, and M. Buchheit, “Reliability of resting and postexercise heart rate measures,” International Journal of Sports Medicine, vol. 32, no. 8, pp. 598–605, 2011.
- A. V. Maker, L. S. Lee, C. P. Raut, T. E. Clancy, and R. S. Swanson, “Cytology from pancreatic cysts has marginal utility in surgical decision-making,” Annals of Surgical Oncology, vol. 15, no. 11, pp. 3187–3192, 2008.
- J. G. Cannon, “Inflammatory cytokines in nonpathological states,” News in Physiological Sciences, vol. 15, no. 6, pp. 298–303, 2000.
- E. J. Fernandez and E. Lolis, “Structure, function, and inhibition of chemokines,” Annual Review of Pharmacology and Toxicology, vol. 42, pp. 469–499, 2002.
- J. B. Rottman, “Key role of chemokines and chemokine receptors in inflammation, immunity, neoplasia, and infectious disease,” Veterinary Pathology, vol. 36, no. 5, pp. 357–367, 1999.
- S. P. FitzGerald, R. I. McConnell, and A. Huxley, “Simultaneous analysis of circulating human cytokines using a high-sensitivity cytokine biochip array,” Journal of Proteome Research, vol. 7, no. 1, pp. 450–455, 2008.
- J. A. Paulo, L. S. Lee, B. Wu, P. A. Banks, H. Steen, and D. L. Conwell, “Cytokine profiling of pancreatic fluid using the ePFT collection method in tandem with a multiplexed microarray assay,” Journal of Immunological Methods, vol. 369, no. 1-2, pp. 98–107, 2011.
- D. V. Sahani, N. I. Sainani, M. A. Blake, S. Crippa, M. Mino-Kenudson, and C. Fernandez Del-Castillo, “Prospective evaluation of reader performance on MDCT in characterization of cystic pancreatic lesions and prediction of cyst biologic aggressiveness,” American Journal of Roentgenology, vol. 197, no. 1, pp. W53–W61, 2011.
- H. Kubo, Y. Chijiiwa, K. Akahoshi et al., “Intraductal papillary-mucinous tumors of the pancreas: differential diagnosis between benign and malignant tumors by endoscopic ultrasonography,” American Journal of Gastroenterology, vol. 96, no. 5, pp. 1429–1434, 2001.
- R. H. Hruban, K. Takaori, D. S. Klimstra et al., “An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms,” American Journal of Surgical Pathology, vol. 28, no. 8, pp. 977–987, 2004.
- K. M. Reid-Lombardo, J. St Sauver, Z. Li, W. A. Ahrens, K. K. Unni, and F. G. Que, “Incidence, prevalence, and management of intraductal papillary mucinous neoplasm in Olmsted County, Minnesota, 1984–2005: a Population Study,” Pancreas, vol. 37, no. 2, pp. 139–144, 2008.
- J. A. Paulo, L. S. Lee, B. Wu et al., “Proteomic analysis of endoscopically (endoscopic pancreatic function test) collected gastroduodenal fluid using in-gel tryptic digestion followed by LC-MS/MS,” Proteomics-Clinical Applications, vol. 4, no. 8-9, pp. 715–725, 2010.
- J. A. Paulo, L. S. Lee, B. Wu et al., “Optimized sample preparation of endoscopic collected pancreatic fluid for SDS-PAGE analysis,” Electrophoresis, vol. 31, no. 14, pp. 2377–2387, 2010.
- J. A. Paulo, L. S. Lee, B. Wu et al., “Identification of pancreas-specific proteins in endoscopically (endoscopic pancreatic function test) collected pancreatic fluid with liquid chromatography-tandem mass spectrometry,” Pancreas, vol. 39, no. 6, pp. 889–896, 2010.
- J. A. Paulo, V. Kadiyala, L. S. Lee, P. A. Banks, D. L. Conwell, and H. Steen, “Proteomic analysis (gelc-ms/ms) of epft-collected pancreatic fluid in chronic pancreatitis,” Journal of Proteome Research, vol. 11, no. 3, pp. 1897–1912, 2012.
- D. Opalka, C. E. Lachman, S. A. MacMullen et al., “Simultaneous quantitation of antibodies to neutralizing epitopes on virus-like particles for human papillomavirus types 6, 11, 16, and 18 by a multiplexed luminex assay,” Clinical and Diagnostic Laboratory Immunology, vol. 10, no. 1, pp. 108–115, 2003.
- R. T. Carson and D. A. A. Vignali, “Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay,” Journal of Immunological Methods, vol. 227, no. 1-2, pp. 41–52, 1999.
- N. Sachdeva and D. Asthana, “Cytokine quantitation: technologies and applications,” Frontiers in Bioscience, vol. 12, no. 12, pp. 4682–4695, 2007.
- D. A. A. Vignali, “Multiplexed particle-based flow cytometric assays,” Journal of Immunological Methods, vol. 243, no. 1-2, pp. 243–255, 2000.
- R. Bender and S. Lange, “Adjusting for multiple testing—when and how?” Journal of Clinical Epidemiology, vol. 54, no. 4, pp. 343–349, 2001.
- M. Tanaka, S. Chari, V. Adsay et al., “International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas,” Pancreatology, vol. 6, no. 1-2, pp. 17–32, 2006.
- M. Tanaka, C. Fernandez-del Castillo, V. Adsay, et al., “International consensus guidelines 2012 for the management of ipmn and mcn of the pancreas,” Pancreatology, vol. 12, no. 3, pp. 183–197, 2012.
- I. Pedrosa and D. Boparai, “Imaging considerations in intraductal papillary mucinous neoplasms of the pancreas,” World Journal of Gastrointestinal Surgery, vol. 2, no. 10, pp. 324–330, 2010.
- K. Shimizu, “Mechanisms of pancreatic fibrosis and applications to the treatment of chronic pancreatitis,” Journal of Gastroenterology, vol. 43, no. 11, pp. 823–832, 2008.
- M. Patel and D. R. Fine, “Fibrogenesis in the pancreas after acinar cell injury,” Scandinavian Journal of Surgery, vol. 94, no. 2, pp. 108–111, 2005.
- V. Ellenrieder, W. Schneiderhan, M. Bachem, and G. Adler, “Fibrogenesis in the pancreas,” Roczniki Akademii Medycznej w Bialymstoku, vol. 49, pp. 40–46, 2004.
- M. V. Apte and J. S. Wilson, “Mechanisms of pancreatic fibrosis,” Digestive Diseases, vol. 22, no. 3, pp. 273–279, 2004.
- A. Masamune, K. Kikuta, T. Watanabe et al., “Fibrinogen induces cytokine and collagen production in pancreatic stellate cells,” Gut, vol. 58, no. 4, pp. 550–559, 2009.
- B. Farrow, D. Albo, and D. H. Berger, “The role of the tumor microenvironment in the progression of pancreatic cancer,” Journal of Surgical Research, vol. 149, no. 2, pp. 319–328, 2008.
- S. Aust, W. Jäger, H. Kirschner, M. Klimpfinger, and T. Thalhammer, “Pancreatic stellate/myofibroblast cells express G-protein-coupled melatonin receptor 1,” Wiener Medizinische Wochenschrift, vol. 158, no. 19-20, pp. 575–578, 2008.
- A. Vonlaufen, M. V. Apte, B. A. Imhof, and J. L. Frossard, “The role of inflammatory and parenchymal cells in acute pancreatitis,” Journal of Pathology, vol. 213, no. 3, pp. 239–248, 2007.
- P. Mews, P. Phillips, R. Fahmy et al., “Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis,” Gut, vol. 50, no. 4, pp. 535–541, 2002.
- M. V. Apte, P. S. Haber, S. J. Darby et al., “Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis,” Gut, vol. 44, no. 4, pp. 534–541, 1999.
- M. Preis and M. Korc :, “Signaling pathways in pancreatic cancer,” Critical Reviews in Eukaryotic Gene Expression, vol. 21, no. 2, pp. 115–129, 2011.
- A. Masamune, T. Watanabe, K. Kikuta, and T. Shimosegawa, “Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis,” Clinical Gastroenterology and Hepatology, vol. 7, no. 11, pp. S48–S54, 2009.
- K. Shimizu, “Pancreatic stellate cells: molecular mechanism of pancreatic fibrosis,” Journal of Gastroenterology and Hepatology, vol. 23, supplement 1, pp. S119–S121, 2008.
- R. Jaster and J. Emmrich, “Crucial role of fibrogenesis in pancreatic diseases,” Best Practice and Research in Clinical Gastroenterology, vol. 22, no. 1, pp. 17–29, 2008.
- G. C. Blobe, W. P. Schiemann, and H. F. Lodish, “Role of transforming growth factor β in human disease,” New England Journal of Medicine, vol. 342, no. 18, pp. 1350–1358, 2000.
- N. Khalil, “TGF-β: from latent to active,” Microbes and Infection, vol. 1, no. 15, pp. 1255–1263, 1999.
- W. U. Guo-Yang, L. U. Qingjun, T. Hasenberg et al., “Association between EGF, TGF-βl, TNF-α gene polymorphisms and cancer of the pancreatic head,” Anticancer Research, vol. 30, no. 12, pp. 5257–5262, 2010.
- J. Y. C. Chow, M. Ban, H. L. Wu et al., “TGF-β downregulates PTEN via activation of NF-κB in pancreatic cancer cells,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 298, no. 2, pp. G275–G282, 2010.
- M. J. Truty and R. Urrutia, “Basics of TGF-β and pancreatic cancer,” Pancreatology, vol. 7, no. 5-6, pp. 423–435, 2007.
- Y. Aoyagi, T. Oda, T. Kinoshita et al., “Overexpression of TGF-β by infiltrated granulocytes correlates with the expression of collagen mRNA in pancreatic cancer,” British Journal of Cancer, vol. 91, no. 7, pp. 1316–1326, 2004.
- V. Ellenrieder, A. Buck, A. Harth et al., “KLF11 mediates a critical mechanism in TGF-β signaling that is inactivated by ERK-MAPK in pancreatic cancer cells,” Gastroenterology, vol. 127, no. 2, pp. 607–620, 2004.
- H. Teraoka, T. Sawada, Y. Yamashita et al., “TGF-beta1 promotes liver metastasis of pancreatic cancer by modulating the capacity of cellular invasion,” International Journal of Oncology, vol. 19, no. 4, pp. 709–715, 2001.
- V. Ellenrieder, S. F. Hendler, C. Ruhland, W. Boeck, G. Adler, and T. M. Gress, “TGF-β-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system,” International Journal of Cancer, vol. 93, no. 2, pp. 204–211, 2001.
- J. Kleeff, T. Ishiwata, H. Maruyama et al., “The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer,” Oncogene, vol. 18, no. 39, pp. 5363–5372, 1999.
- M. Zavoral, P. Minarikova, F. Zavada, C. Salek, and M. Minarik, “Molecular biology of pancreatic cancer,” World Journal of Gastroenterology, vol. 17, no. 24, pp. 2897–2908, 2011.
- M. Groblewska, B. Mroczko, U. Wereszczynska-Siemiatkowska, P. Mysliwiec, B. Kedra, and M. Szmitkowski, “Serum levels of granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF) in pancreatic cancer patients,” Clinical Chemistry and Laboratory Medicine, vol. 45, no. 1, pp. 30–34, 2007.
- S. Joshita, K. Nakazawa, Y. Sugiyama et al., “Granulocyte-colony stimulating factor-producing pancreatic adenosquamous carcinoma showing aggressive clinical course,” Internal Medicine, vol. 48, no. 9, pp. 687–691, 2009.
- K. Ohtsubo, H. Mouri, J. Sakai et al., “Pancreatic cancer associated with granulocyte-colony stimulating factor production confirmed by immunohistochemistry,” Journal of Clinical Gastroenterology, vol. 27, no. 4, pp. 357–360, 1998.
- M. T. Wiekowski, M. W. Leach, E. W. Evans et al., “Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death,” Journal of Immunology, vol. 166, no. 12, pp. 7563–7570, 2001.
- J. L. Langowski, X. Zhang, L. Wu et al., “IL-23 promotes tumour incidence and growth,” Nature, vol. 442, no. 7101, pp. 461–465, 2006.
- O. Barreiro, M. Yáñez-Mó, J. M. Serrador et al., “Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes,” Journal of Cell Biology, vol. 157, no. 7, pp. 1233–1245, 2002.
- H. Kleinhans, J. T. Kaifi, O. Mann et al., “The role of vascular adhesion molecules PECAM-1 (CD 31), VCAM-1 (CD 106), E-selectin (CD62E) and P-selectin (CD62P) in severe porcine pancreatitis,” Histology and Histopathology, vol. 24, no. 5, pp. 551–557, 2009.
- H. B. Pollard, M. Srivastava, O. Eidelman et al., “Protein microarray platforms for clinical proteomics,” Proteomics-Clinical Applications, vol. 1, no. 9, pp. 934–952, 2007.