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Gastroenterology Research and Practice
Volume 2012 (2012), Article ID 317580, 7 pages
http://dx.doi.org/10.1155/2012/317580
Clinical Study

Baseline Serum Cholesterol Is Associated with a Response to Pegylated Interferon Alfa-2b and Ribavirin Therapy for Chronic Hepatitis C Genotype 2

1Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto 1-7-1, Nagasaki 852-8501, Japan
2Department of Gastroenterology and Hepatology, Sasebo City General Hospital, Hirase-machi 9-3, Sasebo 857-8511, Japan
3Department of Gastroenterology and Hepatology, Nagasaki Municipal Hospital, Shinchi-machi 6-39, Nagasaki 850-8555, Japan
4Department of Gastroenterology and Hepatology, Japanese Red Cross Nagasaki Genbaku Hospital, Mori-machi 3-15, Nagasaki 852-8511, Japan
5Department of Gastroenterology and Hepatology, Oita Prefectural Hospital, Bunyo 467, Oita 870-8511, Japan
6Digestive Organ Center, Japan Labour and Welfare Organization, Nagasaki Labour Welfare Hospital, Setogoe 2-12-5, Sasebo 857-0134, Japan
7Department of Gastroenterology and Hepatology, Sasebo Chuo Hospital, Yamato-machi 15, Sasebo 857-1195, Japan
8Department of Internal Medicine, Goto Central Hospital, Nagasaki Prefectural, Yoshikugichou 205, Goto 853-0031, Japan
9Department of Internal Medicine, National Hospital Organization Saga National Hospital, Hinode 1-20-1, Saga 849-8577, Japan
10Department of Internal Medicine, Kouseikai Hospital, Hayama1-3-12, Nagasaki 852-8053, Japan
11Department of Gastroenterology and Hepatology, Medical Inc. Kosei-kai Nijigaoka Hospital, Nijigaoka-machi 1-1, Nagasaki 852-8055, Japan
12Department of Internal Medicine, Caritas Clinic, Nishiizuru-machi 65-7, Nagasaki 851-2322, Japan
13Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki 856-8562, Japan

Received 16 May 2012; Accepted 24 September 2012

Academic Editor: Edoardo Giovanni Giannini

Copyright © 2012 Naota Taura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. HCV infection is associated with lipid disorders because this virus utilizes the host lipid metabolism to sustain its life cycle. Several studies have indicated that higher concentrations of serum cholesterol and LDL before treatment are important predictors of higher rates of sustained virological response (SVR). However, most of these studies involved patients infected with HCV genotype 1. Thus, we performed a multi-institutional clinical study to evaluate the impact of lipid profiles on SVR rates in patients with HCV genotype 2. Methods. A total of 100 chronic hepatitis C patients with HCV genotype 2 who received peg-IFN alfa-2b and ribavirin therapy were consecutively enrolled. The significance of age, sex, BMI, AST level, ALT level, WBC, hemoglobin, platelet count, gamma-glutamyltransferase, total cholesterol level (TC), LDL level, HCV RNA, and histological evaluation was examined for SVR using logistic regression analysis. Results. The 100 patients infected with HCV genotype 2 were divided into 2 groups, an SVR group and a non-SVR group. Characteristics of each group were subsequently compared. There was no significant difference in the level of HCV RNA, BMI, platelet, TG, or stage of fibrosis between the groups. However, there were significant differences in the levels of TC and LDL-C. In multivariate logistic regression analysis using baseline characteristics, high TC level was an independent and significant risk factor (relative risk 18.59, ) for SVR. Conclusion. Baseline serum total cholesterol levels should be considered when assessing the likelihood of sustained treatment response following the course of peg-IFN and ribavirin therapy in patients with chronic HCV genotype 2 infection.