Clinical Study
Baseline Serum Cholesterol Is Associated with a Response to Pegylated Interferon Alfa-2b and Ribavirin Therapy for Chronic Hepatitis C Genotype 2
Table 4
Comparison between HCV patients with high and low serum TC.
| | TC | 177 mg/dL | (Range or %) | 177 mg/dL | (Range or %) | value |
| | Total | 50 | | 50 | | | | Age (y.o.) | 57 | (24–78) | 57 | (36–69) | NS | | Sex (%) | | | | | | | Male | 34 | (68) | 20 | (40) | | | Female | 16 | (32) | 30 | (60) | 0.005 | | BMI (kg/m2) | 21.5 | (18.4–26.8) | 23.5 | (15.4–30.6) | 0.027 | | WBC (/L) | 5100 | (2100–9730) | 5100 | (3000–8300) | NS | | Hemoglobin (g/dL) | 14.2 | (10–16) | 13.9 | (10–16) | NS | | Platelet (104/L) | 17.6 | (7.3–26.5) | 21.7 | (6.9–26.1) | NS | | AST (IU/L) | 48 | (17–377) | 33 | (18–199) | 0.033 | | ALT (IU/L) | 67 | (16–751) | 40 | (11–283) | NS | | TG (mg/dL) | 83 | (46–203) | 111 | (43–262) | NS | | 88 mg/dL (%) | 32 | (63) | 19 | (38) | | | 88 mg/dL (%) | 18 | (37) | 31 | (62) | 0.045 | | LDL-C (mg/dL) | 84 | (43–118) | 121 | (30–167) | 0.001 | | 98 mg/dL (%) | 40 | (79) | 9 | (19) | | | 98 mg/dL (%) | 10 | (21) | 41 | (81) | 0.001 | | HCV RNA (KIU/mL) | 1000 | (20–24200) | 2670 | (20–40900) | 0.029 | | Distribution of stage of fibrosis (%) | | | | | | | 1 | 18 | (36) | 25 | (50) | | | 2 | 7 | (14) | 10 | (20) | | | 3 | 8 | (16) | 3 | (6) | | | 4 | 2 | (4) | 2 | (4) | | | Unknown | 15 | (30) | 10 | (20) | NS | | Distribution of grade of inflammation (%) | | | | | | | 1 | 20 | (40) | 19 | (38) | | | 2 | 14 | (28) | 20 | (40) | | | 3 | 1 | (2) | 1 | (2) | | | Unknown | 15 | (30) | 10 | (20) | NS |
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Data are median (range) or frequency (%).
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