Table 1: LINE-1 methylation level according to H. pylori infection and genetic instability (chromosomal instability and microsatellite instability) in gastric epithelial dysplasia.

LINE-1 methylation (%)P value

Helicobacter pylori Positive5442.40 ± 4.060.34
Negative4641.40 ± 4.21


Chromosomal instability
LOH (−)1740.94 ± 3.970.33
LOH-L4742.80 ± 3.39
LOH-H3641.30 ± 4.13

Microsatellite
state
MSS6442.59 ± 4.530.09
MSI 3640.80 ± 3.44

LOH: loss of heterozygosity; LOH-L: LOH (+) <3 loci; LOH-H: LOH (+) >4 loci; MSS: microsatellite stable; MSI: microsatellite instable, *statistically significant.