Association between Genetic Instability and Helicobacter pylori Infection in Gastric Epithelial Dysplasia

Table 1

LINE-1 methylation level according to H. pylori infection and genetic instability (chromosomal instability and microsatellite instability) in gastric epithelial dysplasia.

		𝑛	LINE-1 methylation (%)	P value
Helicobacter pylori	Positive	54	42.40 ± 4.06	0.34
	Negative	46	41.40 ± 4.21
Chromosomal instability	LOH (−)	17	40.94 ± 3.97	0.33
	LOH-L	47	42.80 ± 3.39
	LOH-H	36	41.30 ± 4.13
Microsatellite; state	MSS	64	42.59 ± 4.53	0.09
	MSI	36	40.80 ± 3.44

LOH: loss of heterozygosity; LOH-L: LOH (+) <3 loci; LOH-H: LOH (+) >4 loci; MSS: microsatellite stable; MSI: microsatellite instable, *statistically significant.