Table 2: LINE-1 methylation level according to genetic instability (chromosomal instability and microsatellite instability) in gastric epithelial dysplasias categorized by the revised Vienna classification.

Category 3 GEDCategory 4 GED
LINE-1 P value LINE-1P value
methylation methylation

Chromosomal instability
LOH (−)844.36 ± 3.430.33939.13 ± 4.390.58
LOH-L2745.61 ± 2.392038.42 ± 3.47
LOH-H1544.02 ± 5.792139.35 ± 3.66

Microsatellite state MSS3545.68 ± 4.410.05*2938.85 ± 4.560.85
MSI 1543.18 ± 3.662139.09 ± 3.98

LOH: loss of heterozygosity; LOH-L: LOH (+) <3 loci; LOH-H: LOH (+) >4 loci; MSS: microsatellite stable; MSI: microsatellite instable, *statistically significant.