Does Cisapride, as a 5HT₄ Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat?

Figure 2

Macroscopic presentation of TNBS-induced colitis in rats. (a) normal rat, i.p; (b)TNBS-control rat, i.p (50 mg/kg); (c) dexamethasone-treated rat, i.p (1 mg/kg); (d) cisapride-treated rat, i.p (2 mg/kg); (e) normal rat, p.o; (f) TNBS-control rat, p.o (50 mg/kg); (g) dexamethasone-treated rat, p.o (2 mg/kg); (h) cisapride-treated rat, p.o (4 mg/kg). Note the extensive hyperemia, edema, ulceration, visible enlargement, and necrosis of the colon in B, D, F, and H groups. In C and G groups the damage score of colon was significantly decreased.

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