Does Cisapride, as a 5HT₄ Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat?

Figure 3

Microscopic presentation of TNBS-induced colitis in rats (hematoxylin and eosin staining; original magnification × 10). (a and b) Normal groups: mucus layer and crypts are normal; (c and d) TNBS-control groups: epithelial distortion, crypt damage, and inflammatory cell infiltrates; (e and f) dexamethasone (i.p and p.o, resp.): moderate mucosal and submucosal inflammation and mucosal inflammatory cell infiltrates; (g and h): cisapride (i.p and p.o, resp.) infiltration of neutrophils and destruction of mucosal architecture.

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