Does Cisapride, as a 5HT4 Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat?
Table 2
Effect of cisapride (2 mg/kg, i.p; 4 mg/kg, p.o: daily) on macroscopic and histopathological parameters of the rat colon 6 days after induction of colitis with TNBS (50 mg/kg).
Group
Colonic weight/length ratio (mg/cm)
Body weight loss after 6 days (%)
Ulcer severity (0–15)
Total colitis index (0–10)
Ulcer area (cm2)
Necrosis (%)
Normal (i.p)
64.8 ± 2.3
−1.9 ± 0.6
0.0
0.0
0.0
0.0
Normal (p.o)
72.1 ± 2.8
−1.6 ± 0.5
0.0
0.0
0.0
0.0
TNBS control (i.p)
256.3 ± 9.5
7.7 ± 0.7
12.2 ± 0.6
9.9 ± 0.1
6.2 ± 0.1
51.5 ± 2.8
TNBS control (p.o)
252.1 ± 9.4
8.2 ± 0.8
11.8 ± 0.7
9.9 ± 0.1
6.0 ± 0.2
48.8 ± 3.8
Cis. (2 mg/kg, i.p)
256.3 ± 7.1
7.1 ± 0.6
12.0 ± 0.5
9.8 ± 0.1
5.7 ± 0.3
48.2 ± 3.5
Cis (4 mg/kg, p.o)
253.1 ± 8.2
8.0 ± 0.9
12.2 ± 0.5
9.5 ± 0.2
6.0 ± 0.3
50.0 ± 1.8
Dex. (1 mg/kg, i.p)
161.9 ± 27.4**
3.9 ± 0.3*
5.33 ± 1.4**
4.8 ± 0.8**
4.0 ± 0.7**
27.0 ± 7.9**
Dex. (2 mg/kg, p.o)
163.5 ± 22.9##
4.7 ± 0.8#
4.7 ± 1.4##
4.9 ± 0.5##
3.9 ± 0.3##
22.2 ± 5.2##
TNBS, 2, 4, 6-trinitrobenzenesulfonic acid, cis: cisapride, dex.: dexamethasone, i.p: intraperitoneal, p.o: oral. Values are means SEM: . and : significant difference compared to TNBS-control group, i.p; and : significant difference compared to TNBS-control group, p.o.
