Does Cisapride, as a 5HT₄ Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat?

Table 3

Biochemical parameters of the rat colon 6 days after induction of colitis with TNBS (50 mg/kg).

Group	MPO activity	TNF-α	IL-6	IL-1β
	(unit/100 mg wet tissue)	(pg/g wet tissue)	(pg/g wet tissue)	(pg/g wet tissue)
Normal (i.p)	0.6 ± 0.1	141.0 ± 13.8	3663.3 ± 240.2	1647.5 ± 452.4
Normal (p.o)	0.6 ± 0.1	144.6 ± 12.7	3646.7 ± 261.0	1768.7 ± 578.8
TNBS control (i.p)	3.4 ± 0.4	249.9 ± 26.6	5210.3 ± 457.9	15296.0 ± 1579.7
TNBS control (p.o)	3.4 ± 0.4	251.8 ± 18.5	5272.0 ± 364.5	15563.4 ± 1476.5
Cis (2 mg/kg, i.p)	3.5 ± 0.3	254.1 ± 21.5	5133.7 ± 352.2	15378.3 ±1252.5
Cis (4 mg/kg, p.o)	3.6 ± 0.2	251.6 ± 15.6	5224.8 ± 263.9	15825.3 ± 1198.2
Dex. (1 mg/kg, i.p)	1.9 ± 0.4^**	160.6 ±12.6^*	3821.7 ± 270.7^*	8641.2 ± 985.2^**
Dex. (2 mg/kg, p.o)	1.8 ± 0.1^##	164.7 ± 10.1^#	3870.7 ± 240.2^#	9162.7 ± 1574.4^#

TNBS: 2, 4, 6-trinitrobenzenesulfonic acid, cis: cisapride, dex.: dexamethasone, i.p: intraperitoneal, p.o: oral.
Values are means ± SEM: 𝑛=6.
^∗∗𝑃<0.01 and ^∗𝑃<0.05: significant difference compared to TNBS-control group, i.p; ^##𝑃<0.01 and ^#𝑃<0.05: significant difference compared to TNBS-control group, p.o.