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Gastroenterology Research and Practice
Volume 2012 (2012), Article ID 371503, 9 pages
Pathogenesis of Helicobacter pylori-Related Gastroduodenal Diseases from Molecular Epidemiological Studies
1Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi,
Yufu-City, Oita 879-5593, Japan
2Department of Medicine-Gastroenterology, Baylor College of Medicine and Michael E. Debakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA
Received 16 March 2012; Accepted 27 April 2012
Academic Editor: Ping-I Hsu
Copyright © 2012 Yoshio Yamaoka. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- H. M. Malaty, “Epidemiology of Helicobacter pylori infection,” Best Practice and Research: Clinical Gastroenterology, vol. 21, no. 2, pp. 205–214, 2007.
- R. A. Alm, L. S. L. Ling, D. T. Moir et al., “Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori,” Nature, vol. 397, no. 6715, pp. 176–180, 1999.
- J. F. Tomb, O. White, A. R. Kerlavage et al., “The complete genome sequence of the gastric pathogen Helicobacter pylori,” Nature, vol. 388, no. 6642, pp. 539–547, 1997.
- J. C. Atherton, “The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases,” Annual Review of Pathology, vol. 1, pp. 63–96, 2006.
- T. L. Cover and S. R. Blanke, “Helicobacter pylori VacA, a paradigm for toxin multifunctionality,” Nature Reviews Microbiology, vol. 3, no. 4, pp. 320–332, 2005.
- J. G. Kusters, A. H. M. Van Vliet, and E. J. Kuipers, “Pathogenesis of Helicobacter pylori infection,” Clinical Microbiology Reviews, vol. 19, no. 3, pp. 449–490, 2006.
- M. Boncristiano, S. R. Paccani, S. Barone et al., “The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms,” Journal of Experimental Medicine, vol. 198, no. 12, pp. 1887–1897, 2003.
- B. Gebert, W. Fischer, E. Weiss, R. Hoffmann, and R. Haas, “Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation,” Science, vol. 301, no. 5636, pp. 1099–1102, 2003.
- M. S. Sundrud, V. J. Torres, D. Unutmaz, and T. L. Cover, “Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of vacA effects on IL-2 secretion,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 20, pp. 7727–7732, 2004.
- J. C. Atherton, P. Cao, R. M. Peek, M. K. R. Tummuru, M. J. Blaser, and T. L. Cover, “Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration,” The Journal of Biological Chemistry, vol. 270, no. 30, pp. 17771–17777, 1995.
- M. Sugimoto, M. R. Zali, and Y. Yamaoka, “The association of vacA genotypes and Helicobacter pylori-related gastroduodenal diseases in the Middle East,” European Journal of Clinical Microbiology and Infectious Diseases, vol. 28, no. 10, pp. 1227–1236, 2009.
- M. Sugimoto and Y. Yamaoka, “The association of vacA genotype and Helicobacter pylori-related disease in Latin American and African populations,” Clinical Microbiology and Infection, vol. 15, no. 9, pp. 835–842, 2009.
- Y. Yamaoka, T. Kodama, O. Gutierrez, J. G. Kim, K. Kashima, and D. Y. Graham, “Relationship between Helicobacter priori iceA, cagA, and vacA status and clinical outcome: studies in four different countries,” Journal of Clinical Microbiology, vol. 37, no. 7, pp. 2274–2279, 1999.
- Y. Yamaoka, E. Orito, M. Mizokami et al., “Helicobacter pylori in North and South America before Columbus,” FEBS Letters, vol. 517, no. 1–3, pp. 180–184, 2002.
- Y. Yamaoka, “Mechanisms of disease: Helicobacter pylori virulence factors,” Nature Reviews Gastroenterology and Hepatology, vol. 7, no. 11, pp. 629–641, 2010.
- T. Uchida, L. T. Nguyen, A. Takayama et al., “Analysis of virulence factors of Helicobacter pylori isolated from a Vietnamese population,” BMC Microbiology, vol. 9, article 175, 2009.
- O. Matsunari, S. Shiota, R. Suzuki, et al., “Association between Helicobacter pylori virulence factors and gastroduodenal diseases in Okinawa, Japan,” Journal of Clinical Microbiology, vol. 50, no. 3, pp. 876–883, 2012.
- J. L. Rhead, D. P. Letley, M. Mohammadi et al., “A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer,” Gastroenterology, vol. 133, no. 3, pp. 926–936, 2007.
- C. Chung, A. Olivares, E. Torres, O. Yilmaz, H. Cohen, and G. Perez-Perez, “Diversity of vacA intermediate region among Helicobacter pylori strains from several regions of the world,” Journal of Clinical Microbiology, vol. 48, no. 3, pp. 690–696, 2010.
- N. R. Hussein, M. Mohammadi, Y. Talebkhan et al., “Differences in virulence markers between Helicobacter pylori strains from Iraq and those from Iran: potential importance of regional differences in H. pylori-associated disease,” Journal of Clinical Microbiology, vol. 46, no. 5, pp. 1774–1779, 2008.
- D. Basso, C. F. Zambon, D. P. Letley et al., “Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms,” Gastroenterology, vol. 135, no. 1, pp. 91–99, 2008.
- K. R. Jones, S. Jang, J. Y. Chang et al., “Polymorphisms in the intermediate region of vacA impact Helicobacter pylori-induced disease development,” Journal of Clinical Microbiology, vol. 49, no. 1, pp. 101–110, 2011.
- H. Ogiwara, D. Y. Graham, and Y. Yamaoka, “vacA i-Region Subtyping,” Gastroenterology, vol. 134, no. 4, p. 1267, 2008.
- R. M. Ferreira, C. Figueiredo, C. Bonet, et al., “Helicobacter pylori-vacA intermediate region genotyping and progression of gastric preneoplastic lesions,” American Journal of Gastroenterology, vol. 107, no. 1, pp. 145–146, 2012.
- H. Ogiwara, M. Sugimoto, T. Ohno et al., “Role of deletion located between the intermediate and middle regions of the Helicobacter pylori
-vacA gene in cases of gastroduodenal diseases,” Journal of Clinical Microbiology, vol. 47, no. 11, pp. 3493–3500, 2009.
- S. Censini, C. Lange, Z. Xiang et al., “cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 25, pp. 14648–14653, 1996.
- S. Backert and M. Selbach, “Role of type IV secretion in Helicobacter pylori pathogenesis,” Cellular Microbiology, vol. 10, no. 8, pp. 1573–1581, 2008.
- M. Hatakeyama, “Oncogenic mechanisms of the Helicobacter pylori CagA protein,” Nature Reviews Cancer, vol. 4, no. 9, pp. 688–694, 2004.
- A. T. Franco, D. A. Israel, M. K. Washington, et al., “Activation of beta-catenin by carcinogenic Helicobacter pylori,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 30, pp. 10646–10651, 2005.
- A. T. Franco, E. Johnston, U. Krishna et al., “Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors,” Cancer Research, vol. 68, no. 2, pp. 379–387, 2008.
- N. Ohnishi, H. Yuasa, and S. Tanaka, “Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse,” Chemtracts, vol. 21, no. 3, pp. 121–123, 2008.
- L. J. Van Doorn, C. Figueiredo, R. Sanna et al., “Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori,” Gastroenterology, vol. 115, no. 1, pp. 58–66, 1998.
- Y. Yamaoka, S. Kikuchi, H. M. T. ElZimaity, O. Gutierrez, M. S. Osato, and D. Y. Graham, “Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production,” Gastroenterology, vol. 123, no. 2, pp. 414–424, 2002.
- Y. Yamaoka, T. Kodama, K. Kashima, D. Y. Graham, and A. R. Sepulveda, “Variants of the 3′ region of the cagA gene in Helicobacter pylori isolates from patients with different H. pylori-associated diseases,” Journal of Clinical Microbiology, vol. 36, no. 8, pp. 2258–2263, 1998.
- Y. Yamaoka, H. M. T. El-Zimaity, O. Gutierrez et al., “Relationship between the cagA 3′ repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH,” Gastroenterology, vol. 117, no. 2, pp. 342–349, 1999.
- Y. Yamaoka, M. S. Osato, A. R. Sepulveda et al., “Molecular epidemiology of Helicobacter pylori: separation of H. pylori from East Asian and non-Asian countries,” Epidemiology and Infection, vol. 124, no. 1, pp. 91–96, 2000.
- M. Miura, N. Ohnishi, S. Tanaka, K. Yanagiya, and M. Hatakeyama, “Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice,” International Journal of Cancer, vol. 125, no. 11, pp. 2497–2504, 2009.
- R. K. Vilaichone, V. Mahachai, S. Tumwasorn, J. Y. Wu, D. Y. Graham, and Y. Yamaoka, “Molecular epidemiology and outcome of Helicobacter pylori infection in Thailand: a cultural cross roads,” Helicobacter, vol. 9, no. 5, pp. 453–459, 2004.
- D. Kersulyte, A. K. Mukhopadhyay, B. Velapatino, et al., “Differences in genotypes of Helicobacter pylori from different human populations,” Journal of Bacteriology, vol. 182, no. 11, pp. 3210–3218, 2000.
- R. H. Argent, M. Kidd, R. J. Owen, R. J. Thomas, M. C. Limb, and J. C. Atherton, “Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori,” Gastroenterology, vol. 127, no. 2, pp. 514–523, 2004.
- T. Azuma, A. Yamakawa, S. Yamazaki et al., “Correlation between variation of the 3′ region of the cagA gene in Helicobacter pylori and disease outcome in Japan,” Journal of Infectious Diseases, vol. 186, no. 11, pp. 1621–1630, 2002.
- S. A. Batista, G. A. Rocha, A. M. C. Rocha et al., “Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer,” BMC Microbiology, vol. 11, article 61, 2011.
- C. Holcombe, B. A. Omotara, J. Eldridge, and D. M. Jones, “H. pylori, the most common bacterial infection in Africa: a random serological study,” American Journal of Gastroenterology, vol. 87, no. 1, pp. 28–30, 1992.
- Y. Xia, Y. Yamaoka, Q. Zhu, I. Matha, and X. Gao, “A comprehensive sequence and disease correlation analyses for the C-terminal region of CagA protein of Helicobacter pylori,” PLoS ONE, vol. 4, no. 11, Article ID e7736, 2009.
- M. Selbach, F. E. Paul, S. Brandt et al., “Host cell interactome of tyrosine-phosphorylated bacterial proteins,” Cell Host and Microbe, vol. 5, no. 4, pp. 397–403, 2009.
- Y. Yamaoka, D. H. Kwon, and D. Y. Graham, “A Mr 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 13, pp. 7533–7538, 2000.
- T. Kudo, H. Lu, J. Y. Wu et al., “Pattern of Transcription Factor Activation in Helicobacter pylori-Infected Mongolian Gerbils,” Gastroenterology, vol. 132, no. 3, pp. 1024–1038, 2007.
- J. Y. Wu, H. Lu, Y. Sun, D. Y. Graham, H. S. Cheung, and Y. Yamaoka, “Balance between polyoma enhancing activator 3 and activator protein 1 regulates Helicobacter pylori-stimulated matrix metalloproteinase 1 expression,” Cancer Research, vol. 66, no. 10, pp. 5111–5120, 2006.
- H. Lu, J. Y. Wu, T. Kudo, T. Ohno, D. Y. Graham, and Y. Yamaoka, “Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with Helicobacter pylori,” Molecular Biology of the Cell, vol. 16, no. 10, pp. 4954–4966, 2005.
- Y. Yamaoka, T. Kudo, H. Lu, A. Casola, A. R. Brasier, and D. Y. Graham, “Role of interferon-stimulated responsive element-like element in interleukin-8 promoter in Helicobacter pylori infection,” Gastroenterology, vol. 126, no. 4, pp. 1030–1043, 2004.
- F. H. Tabassam, D. Y. Graham, and Y. Yamaoka, “OipA plays a role in Helicobacter pylori-induced focal adhesion kinase activation and cytoskeletal re-organization,” Cellular Microbiology, vol. 10, no. 4, pp. 1008–1020, 2008.
- F. H. Tabassam, D. Y. Graham, and Y. Yamaoka, “Helicobacter pylori activate epidermal growth factor receptor- and phosphatidylinositol 3-OH kinase-dependent Akt and glycogen synthase kinase 3β phosphorylation,” Cellular Microbiology, vol. 11, no. 1, pp. 70–82, 2009.
- Y. Yamaoka, O. Ojo, S. Fujimoto et al., “Helicobacter pylori outer membrane proteins and gastroduodenal disease,” Gut, vol. 55, no. 6, pp. 775–781, 2006.
- D. Y. Graham, A. R. Opekun, M. S. Osato et al., “Challenge model for Helicobacter pylori infection in human volunteers,” Gut, vol. 53, no. 9, pp. 1235–1243, 2004.
- Y. Yamaoka, M. Kita, T. Kodama et al., “Helicobacter pylori infection in mice: role of outer membrane proteins in colonization and inflammation,” Gastroenterology, vol. 123, no. 6, pp. 1992–2004, 2002.
- T. Ando, R. M. Peek, D. Pride et al., “Polymorphisms of Helicobacter pylori HP0638 reflect geographic origin and correlate with cagA status,” Journal of Clinical Microbiology, vol. 40, no. 1, pp. 239–246, 2002.
- A. Dossumbekova, C. Prinz, J. Mages et al., “Helicobacter pylori HopH (OipA) and bacterial pathogenicity: genetic and functional genomic analysis of hopH gene polymorphisms,” Journal of Infectious Diseases, vol. 194, no. 10, pp. 1346–1355, 2006.
- P. Lehours, A. Ménard, S. Dupouy et al., “Evaluation of the association of nine Helicobacter pylori virulence factors with strains involved in low-grade gastric mucosa-associated lymphoid tissue lymphoma,” Infection and Immunity, vol. 72, no. 2, pp. 880–888, 2004.
- S. Fujimoto, O. Olaniyi Ojo, A. Arnqvist et al., “Helicobacter pylori BabA Expression, Gastric Mucosal Injury, and Clinical Outcome,” Clinical Gastroenterology and Hepatology, vol. 5, no. 1, pp. 49–58, 2007.
- H. Lu, P. I. Hsu, D. Y. Graham, and Y. Yamaoka, “Duodenal ulcer promoting gene of Helicobacter pylori,” Gastroenterology, vol. 128, no. 4, pp. 833–848, 2005.
- N. R. Hussein, R. H. Argent, C. K. Marx, S. R. Patel, K. Robinson, and J. C. Atherton, “Helicobacter pylori dupA is polymorphic, and its active form induces proinflammatory cytokine secretion by mononuclear cells,” Journal of Infectious Diseases, vol. 202, no. 2, pp. 261–269, 2010.
- Y. Yamaoka, “Roles of the plasticity regions of Helicobacter pylori in gastroduodenal pathogenesis,” Journal of Medical Microbiology, vol. 57, no. 5, pp. 545–553, 2008.
- N. R. Hussein, “The association of dupA and Helicobacter pylori-related gastroduodenal diseases,” European Journal of Clinical Microbiology and Infectious Diseases, vol. 29, no. 7, pp. 817–821, 2010.
- S. Shiota, O. Matsunari, M. Watada, et al., “Systematic review and meta-analysis: the relationship between the Helicobacter pylori dupA gene and clinical outcomes,” Gut Pathogens, vol. 2, no. 1, article 13, 2010.
- D. M. M. Queiroz, G. A. Rocha, A. M. C. Rocha et al., “DupA polymorphisms and risk of Helicobacter pylori-associated diseases,” International Journal of Medical Microbiology, vol. 301, no. 3, pp. 225–228, 2011.
- S. W. Jung, M. Sugimoto, S. Shiota, et al., “The intact dupA cluster is a more reliableHelicobacter pylorivirulence marker than dupA alone,” Infection and Immunity, vol. 80, no. 1, pp. 381–387, 2012.
- W. Fischer, L. Windhager, S. Rohrer et al., “Strain-specific genes of Helicobacter pylori: genome evolution driven by a novel type IV secretion system and genomic island transfer,” Nucleic Acids Research, vol. 38, no. 18, pp. 6089–6101, 2010.
- M. Kawai, Y. Furuta, K. Yahara et al., “Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pylori East Asian genomes,” BMC Microbiology, vol. 11, article 104, 2011.
- M. S. McClain, C. L. Shaffer, D. A. Israel, R. M. Peek, and T. L. Cover, “Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer,” BMC Genomics, vol. 10, article 13, 2009.
- D. McNamara and E. El-Omar, “Helicobacter pylori infection and the pathogenesis of gastric cancer: a paradigm for host-bacterial interactions,” Digestive and Liver Disease, vol. 40, no. 7, pp. 504–509, 2008.
- J. D. Oh, H. Kling-Bäckhed, M. Giannakis et al., “The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 26, pp. 9999–10004, 2006.
- L. Kennemann, X. Didelot, T. Aebischer et al., “Helicobacter pylori genome evolution during human infection,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 12, pp. 5033–5038, 2011.