Pharmacokinetics of the Perioperative Use of Cancer Chemotherapy in Peritoneal Surface Malignancy Patients

Figure 1

Traditional two-compartment model of peritoneal transport in which transfer of a drug from the peritoneal cavity to the blood occurs across the “peritoneal membrane.” The permeability-area product (PA) governs this transfer and can be calculated by measuring the rate of drug disappearance from the cavity and dividing by the overall concentration difference between the peritoneal cavity and the blood (or plasma). 𝐶_𝐵: the free drug concentration in the blood (or plasma); 𝑉_𝐵: volume of distribution of the drug in the body; 𝐶_𝑃: the free drug concentration in the peritoneal fluid; 𝑉_𝑃: volume of the peritoneal cavity. Modified from R. L. Dedrick, M. F. Flessner: pharmacokinetic problems in peritoneal drug administration: Tissue penetration and surface exposure [31].