Table 2: Pharmacokinetic and pharmacodynamic variables involved in the administration of perioperative cancer chemotherapy in peritoneal surface malignancy patients.

Pharmacokinetic variablesPharmacodynamic variables

DoseTemperature
VolumeNodule size of residual tumor
DurationDensity
Carrier solutionBinding
PressureInterstitial fluid pressure
Vasoactive agentsCharge
Macromolecular vehiclesVascularity