The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients
Table 2
Lumbar and femur T-scores, cytokines, hormones and bone metabolism data* of the study population.
Parameter
Control
Cirrhosis
Cirrhosis-viral
Cirrhosis-alcoholic
Alcoholic
Lumbar T score
−0.16 ± 0.97
−0.29 ± 1.04
−0.15 ± 0.97
−0.50 ± 1.12
−0.61 ± 1.54
Femur T Score
0.18 ± 1.38
0.27 ± 1.07
0.35 ± 1.04
0.14 ± 1.13
0.13 ± 1.29
Interleukin 1 (ng/mL)
15.1 ± 55.7
7.6 ± 28.3
11.1 ± 35.8
1.9 ± 2.9
2.0 ± 3.2
Interleukin 2 (ng/mL)
1435 ± 419
2623 ± 875†
2428 ± 637†
2931 ± 1111†
1746 ± 458
Interleukin 6 (ng/mL)
49.6 ± 123.2
73.9 ± 106.0†
76.1 ± 129.7†
70.3 ± 54.8†
43.7 ± 72.6
Interleukin 8 (ng/ml)
106.5 ± 148.6
164.4 ± 169.3
195.8 ± 203.2
114.6 ± 75.0
93.3 ± 79.5
TNF-alpha (ng/mL)
33.4 ± 193.0
−6.3 ± 62.9
3.2 ± 78.7
−21.3 ± 14.0
−27.4 ± 10.1
Vitamin D
16.9 ± 17.3
23 ± 30
16.2 ± 21.0
34.9 ± 38.5
29 ± 26.5
Total testosterone
434.7 ± 147.4
462 ± 268
474 ± 277
442 ± 260
688 ± 204‡
Parathormone
38.6 ± 7.7
49.0 ± 25.7
49.9 ± 28.9
47.7 ± 20.6
47.0 ± 15.1
Osteocalcin (μg/L)
14.8 ± 5.5¶
4.2 ± 2.8
4.6 ± 3.0
3.6 ± 2.3
7.9 ± 5.7
Calcitonin
9.0 ± 2.0
6.3 ± 3.1
6.0 ± 2.6
6.9 ± 3.9
6.3 ± 2.8
Calcium
9.3 ± 0.3
8.3 ± 0.6
8.3 ± 0.7§
8.3 ± 0.6§
9.0 ± 0.4
Phosphorus
2.9 ± 0.4
3.1 ± 0.8
2.9 ± 0.7
3.5 ± 0.8
3.2 ± 0.7
Urinary calcium
89.2 ± 57.7
165 ± 100
162 ± 96
172 ± 109
130 ± 83
Urinary phosphorus
757 ± 873
649 ± 432
629 ± 435
681 ± 440
533 ± 384
T3
3.2 ± 0.7
2.4 ± 0.7
2.5 ± 0.7
2.3 ± 0.6z
2.8 ± 0.7
T4
1.5 ± 0.3
1.2 ± 0.3
1.2 ± 0.3
1.3 ± 0.3
1.4 ± 0.2
TSH
1.5 ± 0.9
1.2 ± 0.8
1.0 ± 0.6ß
1.4 ± 1.0 ß
1.8 ± 0.9
Data are presented as mean ± standard deviation. †P < 0.001 versus controls, ‡P < 0.01 versus controls and cirrhosis, ¶P < 0.001 versus all others, §P < 0.001 versus group 1 and 2, zP < 0.05 versus all others, ßP < 0.05 versus controls and alcoholics.