431451.fig.004a
(a) Representative image of proximal pancreas of animal no. 1, showing a localized area of tissue necrosis consistent with acute pancreatitis (arrows). (H&E, original magnification 40x)
431451.fig.004b
(b) Higher power image of pancreatitis showing histologic evidence of cellular apoptosis and necrosis consistent with cell death (shrunken fragmented nuclei and dissolution of cell membranes). (H&E, original magnification 400x)
431451.fig.004c
(c) Adjoining area of pancreas showing normal histology of acinar cells with no evidence of pancreatitis or other cellular injury. (H&E, original magnification 400x)
431451.fig.004d
(d) Example of fat necrosis (left side of image) in adjacent extrapancreatic adipose tissue from the proximal potion of animal no. 5. (H&E, original magnification 100x)
Figure 4: Pancreatic histology.