The Evolution of Dieulafoy's Lesion Since 1897: Then and Now—A Journey through the Lens of a Pediatric Lesion with Literature Review
Figure 2
Histopathological findings. (a) Whole-mount scan of hematoxylin and eosin stained slide showing the exulceratio simplex (*) in the submucosa (SM) (below the mucosa (M)) as described by Dieulafoy. Additionally, (#) shows the presence of a complex rich anastomosis of varying sized vessels in the submucosa with an intraluminal haemorrhagic thrombus (cirsoid aneurysm of gastric vessels). (b) Low magnification (objective lens ×2) of hematoxylin and eosin-stained slides shows the presence of blood within the large tortuous, caliber-persistent artery () in the submucosa (SM) with evidence of rupture and haemorrhage (#) through the overlying mucosa (M). A normal-sized submucosal arteriole (*) is seen at the same level. (c) High magnification (objective lens ×10) of hematoxylin and eosin-stained slides shows the presence of the large caliber-persistent artery () in the submucosa (SM)—Dieulafoy’s lesion—with communications (#) into the overlying noninflamed mucosa (M). (d) High magnification (objective lens ×10) of elastin-stained slides shows the presence of elastin in the wall (#) of the exulceratio simplex confirming its arterial origin.
