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Gastroenterology Research and Practice
Volume 2012 (2012), Article ID 561207, 7 pages
http://dx.doi.org/10.1155/2012/561207
Research Article

Pantoprazole before Endoscopy in Patients with Gastroduodenal Ulcer Bleeding: Does the duration of Infusion and Ulcer Location Influence the Effects?

1Department of Gastroenterology, Petz Aladár Teaching Hospital, Győr 9024, Hungary
2Department of Mathematics and Computer Sciences, Széchenyi István University, Győr 9026, Hungary

Received 15 June 2012; Accepted 14 September 2012

Academic Editor: Sergio Morini

Copyright © 2012 Istvan Rácz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to investigate the effect of preemptive pantoprazole infusion on early endoscopic findings in patients with acute ulcer bleeding. Records of 333 patients admitted with acute ulcer bleeding were analyzed. Ulcer bleeders were given either 80 mg bolus of pantoprazole followed by continuous infusion of 8 mg per hour or saline infusion until endoscopy. In 93 patients saline infusion whereas in 240 patients bolus plus infusion of pantoprazole was administrated with mean (±SD) durations of hours and hours, respectively ( ). Actively bleeding ulcers were detected in 46/240 (19.2%) of cases in the pantoprazole group as compared with 23/93 (24.7%) in the saline infusion group ( ). Different durations of pantoprazole infusion (0–4 hours, 4 hours, and 6 hours) had no significant effect on endoscopic and clinical outcome parameters in duodenal ulcer bleeders. Gastric ulcer bleeders on pantoprazole infusion longer than 4 and 6 hours before endoscopy had actively bleeding ulcers in 4.3% and 5% compared to the 19.5% active bleeding rate in the saline group ( and ). Preemptive infusion of high-dose pantoprazole longer than 4 hours before endoscopy decreased the ratio of active bleeding only in gastric but not in duodenal ulcer patients.