Atypical Celiac Disease: From Recognizing to Managing

Table 3

Characteristics of exclusive or combined serological tests used to detect CD [11, 13, 18, 32].

Serological tests	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
IgG AGA	57–78	71–87	20–90	40–90
IgA AGA	55–100	65–100	30–100	70–100
IgA EMA	86–100	98–100	98–100	80–95
IgA tTG	90–96	91–97	>90	>95
IgA tTG and EMA	98–100	98–100	>90	>95
IgA DGP	98	94	92	98
IgG DGP	97	100	100	97
IgA DGP + IgA tTG	100	93	91	100
IgG DGP + IgA tTG	100	97	97	100

IgG: immunoglobulin G; IgA: immunoglobulin A; AGA: antigliadin antibodies; EMA: endomysial antibodies; tTG: tissue transglutaminase; DGP: deamidated gliadin peptide; PPV: positive predictive value; NPV: negative predictive value.