Table 3: Characteristics of exclusive or combined serological tests used to detect CD [11, 13, 18, 32].

Serological testsSensitivity (%)Specificity (%)PPV (%)NPV (%)

IgG AGA57–7871–8720–9040–90
IgA AGA55–10065–10030–10070–100
IgA EMA 86–100 98–10098–10080–95
IgA tTG90–9691–97>90>95
IgA tTG and EMA98–10098–100>90>95
IgA DGP98949298
IgG DGP9710010097
IgA DGP + IgA tTG1009391100
IgG DGP + IgA tTG1009797100

IgG: immunoglobulin G; IgA: immunoglobulin A; AGA: antigliadin antibodies; EMA: endomysial antibodies; tTG: tissue transglutaminase; DGP: deamidated gliadin peptide; PPV: positive predictive value; NPV: negative predictive value.