Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population

Table 3

Phenotypic analysis results.

rs10902469: G

rs7953348: T

rs7488085: T

rs11616018: T

rs12303764: T

rs3088051: C

rs3923716: C

OR (95% CI)

𝑃

OR (95% CI)

𝑃

OR (95% CI)

𝑃

OR (95% CI)

𝑃

OR (95% CI)

𝑃

OR (95% CI)

𝑃

OR (95% CI)

𝑃

Age at diagnosis

<17

0.98 (0.44–2.18)

0.953

0.97 (0.58–1.64)

0.912

0.90 (0.44–1.85)

0.770

1.15 (0.66–2.01)

0.634

0.94 (0.61–1.43)

0.761

1.05 (0.65–1.70)

0.836

0.93 (0.46–1.86)

0.827

17 to 40

1.90 (1.17–3.10)

0.010*

1.11 (0.86–1.44)

0.436

1.53 (1.01–2.32)

0.044

1.15 (0.88–1.50)

0.298

1.17 (0.95–1.45)

0.142

1.18 (0.94–1.48)

0.165

1.03 (0.73–1.46)

0.852

40<

1.37 (0.62–3.04)

0.435

1.35 (0.82–2.22)

0.241

1.14 (0.57–2.25)

0.715

1.35 (0.81–2.26)

0.245

1.11 (0.77–1.61)

0.580

1.33 (0.90–1.97)

0.151

1.53 (0.75–3.11)

0.243

CD; behaviour

Inflammatory

2.63 (1.42–4.86)

0.002*

1.25 (0.93–1.68)

0.139

1.79 (1.10–2.91)

0.018*

1.25 (0.93–1.69)

0.143

1.07 (0.85–1.35)

0.554

1.06 (0.82–1.36)

0.667

1.19 (0.80–1.76)

0.396

Stricturing

1.19 (0.68–2.10)

0.547

1.00 (0.71–1.41)

0.994

1.19 (0.70–2.01)

0.516

1.17 (0.82–1.68)

0.392

1.20 (0.89–1.60)

0.229

1.45 (1.08–1.95)

0.015*

1.02 (0.64–1.63)

0.943

Penetrating

0.84 (0.39–1.81)

0.658

0.97 (0.58–1.63)

0.912

0.72 (0.37–1.39)

0.323

0.95 (0.57–1.60)

0.850

1.29 (0.83–2.01)

0.265

1.17 (0.73–1.86)

0.509

0.85 (0.44–1.65)

0.633

CD; location

Ileal

1.62 (0.89–2.94)

0.116

1.20 (0.85–1.69)

0.295

1.57 (0.91–2.70)

0.104

1.22 (0.87–1.73)

0.254

1.11 (0.85–1.45)

0.430

1.34 (1.01–1.78)

0.042*

1.15 (0.73–1.82)

0.541

Colonic

2.33 (1.11–4.89)

0.025*

1.34 (0.92–1.95)

0.124

1.58 (0.88–2.81)

0.123

1.33 (0.91–1.95)

0.137

1.08 (0.82–1.44)

0.586

1.00 (0.73–1.37)

0.992

1.27 (0.77–2.09)

0.345

Ileocolonic

1.19 (0.66–2.13)

0.565

0.89 (0.63–1.25)

0.499

0.99 (0.59–1.64)

0.954

1.01 (0.71–1.45)

0.951

1.19 (0.89–1.60)

0.245

1.21 (0.88–1.66)

0.237

0.86 (0.54–1.36)

0.517

Other IBD family

Y

6.10 (0.84–44.4)

0.075

1.01 (0.73–1.39)

0.968

3.67 (0.88–15.2)

0.073

1.40 (0.72–2.73)

0.327

1.08 (0.68–1.74)

0.737

1.24 (0.75–2.04)

0.412

2.07 (0.74–5.81)

0.169

Bowel resection

Y

1.12 (0.66–1.90)

0.674

0.99 (0.56–1.74)

0.963

1.09 (0.68–1.77)

0.717

1.22 (0.86–1.73)

0.270

1.18 (0.90–1.56)

0.225

1.58 (1.19–2.10)

0.002*

0.95 (0.61–1.46)

0.802

Perianal disease

Y

1.70 (0.67–4.29)

0.262

0.74 (0.48–1.16)

0.186

0.79 (0.42–1.50)

0.473

0.82 (0.52–1.30)

0.398

1.46 (0.96–2.23)

0.079

1.10 (0.71–1.71)

0.676

0.62 (0.36–1.09)

0.099

*Remain statistically significant after applying a multiple testing correction using FDR.