723183.fig.001
Figure 1: H. pylori oscillates between a replicating state (antibiotic sensitivity) and nonreplicating state (antibiotic insensitivity) according to the pH in the microenvironments, and PPI synergizes with the antibiotics by effectively increasing gastric pH and disrupts the acidic environment preferred by HP. PPI: proton pump inhibitor, A: amoxicillin, C: clarithromycin.