Table 2: Four different combined intraperitoneal and intravenous chemotherapy (bidirectional) treatment options.

DiseaseCombined intraperitoneal and intravenous chemotherapy treatment option

Peritoneal mesotheliomaPemetrexed (500 mg/m2) in 1000 mL 1.5% dextrose peritoneal dialysis solution as a 60-minute rapid infusion through the intraperitoneal port. Cisplatin (75 mg/m2) in 250 mg of normal saline is given over 120 minutes immediately following the pemetrexed infusion.

Adenocarcinoma5-fluorouracil (600 mg/m2) in 1000 mL 1.5% dextrose peritoneal dialysis solution through the intraperitoneal port with the administration as rapid as possible. After the intraperitoneal chemotherapy infusion is complete, oxaliplatin (130 mg/m2) in 250 mL of dextrose in water is given as a 2-hour intravenous infusion.

Pancreas cancerGemcitabine (1000 mg/m2) in 1000 mL 1.5% dextrose peritoneal dialysis solution through the intraperitoneal port as rapid as possible is given on days 1, 8, and 15 of a 4-week cycle.

Papillary serous and ovarian cancerPaclitaxel (20 mg/m2) in 1000 mL 6% Hetastarch through the intraperitoneal port. Intravenous cisplatin (75 mg/m2) is given after the paclitaxel infusion is complete over 120 minutes.