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Gastroenterology Research and Practice
Volume 2012 (2012), Article ID 752940, 6 pages
Effect of Non-Anticoagulant N-Desulfated Heparin on Basic Fibroblast Growth Factor Expression, Angiogenesis, and Metastasis of Gastric Carcinoma In Vitro and In Vivo
1Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China
2Department of Gastroenterology, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
3Shanghai Laboratory Animal Center, Chinese Academy of Sciences, Shanghai 200031, China
Received 20 April 2012; Accepted 11 June 2012
Academic Editor: Richard Ricachenevski Gurski
Copyright © 2012 Jin-Lian Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- P. Carmeliet and R. K. Jain, “Angiogenesis in cancer and other diseases,” Nature, vol. 407, no. 6801, pp. 249–257, 2000.
- P. H. Maxwell, G. U. Dachs, J. M. Gleadle et al., “Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 15, pp. 8104–8109, 1997.
- J. S. Mader, D. Smyth, J. Marshall, and D. W. Hoskin, “Bovine lactoferricin inhibits basic fibroblast growth factor- and vascular endothelial growth factor165-induced angiogenesis by competing for heparin-like binding sites on endothelial cells,” The American Journal of Pathology, vol. 169, no. 5, pp. 1753–1766, 2006.
- H. J. Lee, E. O. Lee, Y. H. Rhee et al., “An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis,” Carcinogenesis, vol. 27, no. 12, pp. 2455–2463, 2006.
- I. Vucenik, A. Passaniti, M. I. Vitolo, K. Tantivejkul, P. Eggleton, and A. M. Shamsuddin, “Anti-angiogenic activity of inositol hexaphosphate (IP6),” Carcinogenesis, vol. 25, no. 11, pp. 2115–2123, 2004.
- H. Zhao, H. Liu, Y. Chen et al., “Oligomannurarate sulfate, a novel heparanase inhibitor simultaneously targeting basic fibroblast growth factor, combats tumor angiogenesis and metastasis,” Cancer Research, vol. 66, no. 17, pp. 8779–8787, 2006.
- S. Javerzat, P. Auguste, and A. Bikfalvi, “The role of fibroblast growth factors in vascular development,” Trends in Molecular Medicine, vol. 8, no. 10, pp. 483–489, 2002.
- D. Ribatti, “The crucial role of vascular permeability factor/vascular endothelial growth factor in angiogenesis: a historical review,” British Journal of Haematology, vol. 128, no. 3, pp. 303–309, 2005.
- Y. D. Jung, P. F. Mansfield, M. Akagi et al., “Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model,” European Journal of Cancer, vol. 38, no. 8, pp. 1133–1140, 2002.
- N. Reinmuth, A. A. Parikh, S. A. Ahmad et al., “Biology of angiogenesis in tumors of the gastrointestinal tract,” Microscopy Research and Technique, vol. 60, no. 2, pp. 199–207, 2003.
- A. Falanga and M. Marchetti, “Heparin in tumor progression and metastatic dissemination,” Seminars in Thrombosis and Hemostasis, vol. 33, no. 7, pp. 688–694, 2007.
- J. L. Stevenson, A. Varki, and L. Borsig, “Heparin attenuates metastasis mainly due to inhibition of P- and L-selectin, but non-anticoagulant heparins can have additional effects,” Thrombosis Research, vol. 120, supplement 2, pp. S107–S111, 2007.
- A. Naggi, B. Casu, M. Perez et al., “Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting,” Journal of Biological Chemistry, vol. 280, no. 13, pp. 12103–12113, 2005.
- J. L. Chen, W. X. Chen, J. S. Zhu et al., “Effect of P-selectin monoclonal antibody on metastasis of gastric cancer and immune function,” World Journal of Gastroenterology, vol. 9, no. 7, pp. 1607–1610, 2003.
- S. A. Lang, D. Klein, C. Moser et al., “Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo,” Molecular Cancer Therapeutics, vol. 6, no. 3, pp. 1123–1132, 2007.
- N. Wang, B. Wang, and Y. J. Wang, “Effect of vascular endothelial growth factor antibody Avastin on angiogenesis of human gastric cancer growing orthotopically in nude mice,” Ai Zheng, vol. 25, no. 9, pp. 1076–1081, 2006.
- Y. L. Wu, S. L. Fu, Y. P. Zhang, M. M. Qiao, and Y. Chen, “Cyclooxygenase-2 inhibitors suppress angiogenesis and growth of gastric cancer xenografts,” Biomedicine and Pharmacotherapy, vol. 59, supplement 2, pp. S289–S292, 2005.
- C. Pisano, C. Aulicino, L. Vesci et al., “Undersulfated, low-molecular-weight glycol-split heparin as an antiangiogenic VEGF antagonist,” Glycobiology, vol. 15, no. 2, pp. 1C–6C, 2005.
- B. Casu, M. Guerrini, S. Guglieri et al., “Undersulfated and glycol-split heparins endowed with antiangiogenic activity,” Journal of Medicinal Chemistry, vol. 47, no. 4, pp. 838–848, 2004.
- T. Zhou, J. L. Chen, W. Song et al., “Effect of N-desulfated heparin on hepatic/renal ischemia reperfusion injury in rats,” World Journal of Gastroenterology, vol. 8, no. 5, pp. 897–900, 2002.
- D. Y. Lee, S. K. Kim, Y. S. Kim et al., “Suppression of angiogenesis and tumor growth by orally active deoxycholic acid-heparin conjugate,” Journal of Controlled Release, vol. 118, no. 3, pp. 310–317, 2007.
- G. C. Jayson and J. T. Gallagher, “Heparin oligosaccharides: inhibitors of the biological activity of bFGF on Caco-2 cells,” British Journal of Cancer, vol. 75, no. 1, pp. 9–16, 1997.
- K. Norrby, “2.5 kDa and 5.0 kDa heparin fragments specifically inhibit microvessel sprouting and network formation in VEFG165-mediated mammalian angiogenesis,” International Journal of Experimental Pathology, vol. 81, no. 3, pp. 191–198, 2000.
- K. Ono, M. Ishihara, K. Ishikawa et al., “Periodate-treated, non-anticoagulant heparin-carrying polystyrene (NAC-HCPS) affects angiogenesis and inhibits subcutaneous induced tumour growth and metastasis to the lung,” British Journal of Cancer, vol. 86, no. 11, pp. 1803–1812, 2002.
- S. A. Mousa and S. Mohamed, “Anti-angiogenic mechanisms and efficacy of the low molecular weight heparin, tinzaparin: anti-cancer efficacy,” Oncology Reports, vol. 12, no. 4, pp. 683–688, 2004.
- I. Vlodavsky, Z. Fuks, R. Ishai-Michaeli et al., “Extracellular matrix-resident basic fibroblast growth factor: implication for the control of angiogenesis,” Journal of Cellular Biochemistry, vol. 45, no. 2, pp. 167–176, 1991.
- M. V. Cronauer, A. Hittmair, I. E. Eder et al., “Basic fibroblast growth factor levels in cancer cells and in sera of patients suffering from proliferative disorders of the prostate,” Prostate, vol. 31, Article ID 9180932, pp. 223–233, 1997.
- A. Birck, A. F. Kirkin, J. Zeuthen, and K. Hou-Jensen, “Expression of basic fibroblast growth factor and vascular endothelial growth factor in primary and metastatic melanoma from the same patients,” Melanoma Research, vol. 9, no. 4, pp. 375–381, 1999.
- M. R. Sartippour, L. Zhang, M. Lu, H. J. Wang, and M. N. Brooks, “Nipple fluid basic fibroblast growth factor in patients with breast cancer,” Cancer Epidemiology Biomarkers and Prevention, vol. 14, no. 12, pp. 2995–2998, 2005.
- C. Barclay, A. W. Li, L. Geldenhuys et al., “Basic fibroblast growth factor (FGF-2) overexpression is a risk factor for esophageal cancer recurrence and reduced survival, which is ameliorated by coexpression of the FGF-2 antisense gene,” Clinical Cancer Research, vol. 11, no. 21, pp. 7683–7691, 2005.
- M. Hatziapostolou, C. Polytarchou, P. Katsoris, J. Courty, and E. Papadimitriou, “Heparin affin regulatory peptide/pleiotrophin mediates fibroblast growth factor 2 stimulatory effects on human prostate cancer cells,” Journal of Biological Chemistry, vol. 281, no. 43, pp. 32217–32226, 2006.
- O. E. Pardo, C. Wellbrock, U. K. Khanzada et al., “FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCε, B-Raf and S6K2,” EMBO Journal, vol. 25, no. 13, pp. 3078–3088, 2006.
- J. Zhao, X. Y. Liu, Q. Y. Zhang, and W. Jiang, “Plasma level and prognostic significance of VEGF, bFGF and MMP-9 in patients with advanced non-small-cell lung cancer,” Zhonghua Zhong Liu Za Zhi, vol. 27, no. 11, pp. 676–679, 2005.
- K. Yonemaru, H. Sakai, M. Murakami, T. Yanai, and T. Masegi, “Expression of vascular endothelial growth factor, basic fibroblast growth factor, and their receptors (flt-1, flk-1, and flg-1) in canine vascular tumors,” Veterinary Pathology, vol. 43, no. 6, pp. 971–980, 2006.