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Gastroenterology Research and Practice
Volume 2012 (2012), Article ID 756263, 6 pages
http://dx.doi.org/10.1155/2012/756263
Clinical Study

The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran

1Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
2Gastrointestinal and Liver Diseases Research Center (GLDRC), Razi Hospital, Guilan University of Medical Sciences, Sardar-Jangle Avenue, P.O. Box 41448-95655, Rasht, Iran
3Genomics & Animal Department, Agricultural Biotechnology Research Institute of North Region, Rasht, Iran

Received 15 May 2012; Revised 9 September 2012; Accepted 14 October 2012

Academic Editor: Akira Andoh

Copyright © 2012 Masoumeh Faghani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The aim of this study was to determine the correlation between MSI and sporadic colorectal cancer in Guilan province, North part of Iran. Materials and Methods. A total of 96 patients who underwent resection for sporadic colorectal cancer in Guilan province were studied. No patients had positive family history of cancers. The frequencies of MSI were analyzed by testing the BAT-26 and BAT-25 markers. Results. MSI analysis revealed that 22.9% of the tumors (22 patients) were microsatellite instability positive and 77.1% (74 patients) were microsatellite instability negative. The highest rate of MSI (40.9%) was found in the rectal region. MSI-H status was seen more frequently in distal tumors ( , odds ratio = 3.13, 0.96–10.14). Conclusions. Distal tumor location and MSI may associate with special clinicopathological features. It seems that there may be correlation with underlying genetic and immunologic mechanisms.