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Gastroenterology Research and Practice
Volume 2012 (2012), Article ID 756263, 6 pages
doi:10.1155/2012/756263
Clinical Study

The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran

Masoumeh Faghani,1 Saba Fakhrieh Asl,2 Fariborz Mansour-Ghanaei,2 Keyvan Aminian,2 Alireza Tarang,3 Ramin Seighalani,3 and Azadeh Javadi3

1Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
2Gastrointestinal and Liver Diseases Research Center (GLDRC), Razi Hospital, Guilan University of Medical Sciences, Sardar-Jangle Avenue, P.O. Box 41448-95655, Rasht, Iran
3Genomics & Animal Department, Agricultural Biotechnology Research Institute of North Region, Rasht, Iran

Received 15 May 2012; Revised 9 September 2012; Accepted 14 October 2012

Academic Editor: Akira Andoh

Copyright © 2012 Masoumeh Faghani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. M. Parkin, F. Bray, J. Ferlay, and P. Pisani, “Global cancer statistics, 2002,” CA Cancer Journal for Clinicians, vol. 55, no. 2, pp. 74–108, 2005. View at Scopus
  2. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, “Global cancer statistics,” CA Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Mahdavinia, F. Bishehsari, R. Ansari et al., “Family history of colorectal cancer in Iran,” BMC Cancer, vol. 5, p. 112, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Kolahdoozan, A. Sadjadi, A. R. Radmard, and H. Khademi, “Five common cancers in Iran,” Archives of Iranian Medicine, vol. 13, no. 2, pp. 143–146, 2010. View at Scopus
  5. M. Redston, “Carcinogenesis in the GI tract: from morphology to genetics and back again,” Modern Pathology, vol. 14, no. 3, pp. 236–245, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. C. C. Compton, “Colorectal carcinoma: diagnostic, prognostic, and molecular features,” Modern Pathology, vol. 16, no. 4, pp. 376–388, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. S. N. Thibodeau, G. Bren, and D. Schaid, “Microsatellite instability in cancer of the proximal colon,” Science, vol. 260, no. 5109, pp. 816–819, 1993. View at Scopus
  8. C. R. Boland, S. N. Thibodeau, S. R. Hamilton et al., “A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer,” Cancer Research, vol. 58, no. 22, pp. 5248–5257, 1998. View at Scopus
  9. S. Popat, R. Hubner, and R. S. Houlston, “Systematic review of microsatellite instability and colorectal cancer prognosis,” Journal of Clinical Oncology, vol. 23, no. 3, pp. 609–618, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Watanabe, T. T. Wu, P. J. Catalano et al., “Molecular predictors of survival after adjuvant chemotherapy for colon cancer,” The New England Journal of Medicine, vol. 344, no. 16, pp. 1196–1206, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Q. Huang, Y. Yuan, W. T. Ge, H. G. Hu, S. Z. Zhang, and S. Zheng, “Comparative features of colorectal and gastric cancers with microsatellite instability in Chinese patients,” Journal of Zhejiang University B, vol. 11, no. 9, pp. 647–653, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. F. A. Sinicrope, R. L. Rego, K. C. Halling et al., “Prognostic impact of microsatellite instability and DNA ploidy in human colon carcinoma patients,” Gastroenterology, vol. 131, no. 3, pp. 729–737, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. I. Esemuede, A. Forslund, S. A. Khan et al., “Improved testing for microsatellite instability in colorectal cancer using a simplified 3-marker assay,” Annals of Surgical Oncology, vol. 17, no. 12, pp. 3370–3378, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Redston, “Carcinogenesis in the GI tract: from morphology to genetics and back again,” Modern Pathology, vol. 14, no. 3, pp. 236–245, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. K. F. Pan, W. Liu, Y. Y. Lu et al., “High throughput detection of microsatellite instability by denaturing high-performance liquid chromatography,” Human Mutation, vol. 22, no. 5, pp. 388–394, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. S. B. Hatch, H. M. Lightfoot Jr., C. P. Garwacki et al., “Microsatellite instability testing in colorectal carcinoma: choice of markers affects sensitivity of detection of mismatch repair-deficient tumors,” Clinical Cancer Research, vol. 11, no. 6, pp. 2180–2187, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. M. . Nikbahkt Dastjerdi, M. Faghani, M. Salehi, and M. Rabbani, “A preliminary study of microsatellite instability analysis in different genotypes of p53 codon 72 in breast invasive ductal carcinomas,” Medical Journal of the Islamic Republic of Iran, vol. 23, pp. 83–89, 2009.
  18. A. Loukola, K. Eklin, P. Laiho et al., “Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC),” Cancer Research, vol. 61, no. 11, pp. 4545–4549, 2001. View at Scopus
  19. S. Jacob and F. Praz, “DNA mismatch repair defects: role in colorectal carcinogenesis,” Biochimie, vol. 84, no. 1, pp. 27–47, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Lage and M. Dietel, “Involvement of the DNA mismatch repair system in antineoplastic drug resistance,” Journal of Cancer Research and Clinical Oncology, vol. 125, no. 3-4, pp. 156–165, 1999. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Azzoni, L. Bottarelli, S. Cecchini, E. M. Silini, C. Bordi, and L. Sarli, “Sporadic colorectal carcinomas with low-level microsatellite instability: a distinct subgroup with specific clinicopathological and molecular features,” International journal of colorectal disease, vol. 26, no. 4, pp. 445–453, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Koi, A. Umar, D. P. Chauhan et al., “Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation,” Cancer Research, vol. 54, no. 16, pp. 4308–4312, 1994. View at Scopus
  23. D. Fink, S. Nebel, S. Aebi et al., “The role of DNA mismatch repair in platinum drug resistance,” Cancer Research, vol. 56, no. 21, pp. 4881–4886, 1996. View at Scopus
  24. G. Marra, S. D'Atri, C. Corti et al., “Tolerance of human MSH2+/- lymphoblastoid cells to the methylating agent temozolomide,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 13, pp. 7164–7169, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. H. Kim, B. H. Min, S. J. Kim et al., “Difference between proximal and distal microsatellite-unstable sporadic colorectal cancers: analysis of clinicopathological and molecular features and prognoses,” Annals of Surgical Oncology, vol. 17, no. 5, pp. 1435–1441, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. I. Esemuede, A. Forslund, S. A. Khan et al., “Improved testing for microsatellite instability in colorectal cancer using a simplified 3-marker assay,” Annals of Surgical Oncology, vol. 17, no. 12, pp. 3370–3378, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. J. M. D. Wheeler, A. Loukola, L. A. Aaltonen, N. J. McC Mortensen, and W. F. Bodmer, “The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI+ sporadic colorectal cancers,” Journal of Medical Genetics, vol. 37, no. 8, pp. 588–592, 2000. View at Scopus
  28. H. Zhang, B. Richards, T. Wilson et al., “Apoptosis induced by overexpression of hMSH2 or hMLH1,” Cancer Research, vol. 59, no. 13, pp. 3021–3027, 1999. View at Scopus
  29. A. Ichikawa, K. Sugano, and S. Fujita, “DNA variants of BAT-25 in Japanese, a locus frequently used for analysis of microsatellite instability,” Japanese Journal of Clinical Oncology, vol. 31, no. 7, pp. 346–348, 2001. View at Scopus
  30. R. Pyatt, R. B. Chadwick, C. K. Johnson, C. Adebamowo, A. De La Chapelle, and T. W. Prior, “Polymorphic variation at the BAT-25 and BAT-26 loci in individuals of African origin: implications for microsatellite instability testing,” American Journal of Pathology, vol. 155, no. 2, pp. 349–353, 1999. View at Scopus
  31. R. Malekzadeh, F. Bishehsari, M. Mahdavinia, and R. Ansari, “Epidemiology and molecular genetics of colorectal cancer in Iran: a review,” Archives of Iranian Medicine, vol. 12, no. 2, pp. 161–169, 2009. View at Scopus
  32. K. Søreide, B. S. Nedrebø, J. A. Søreide, A. Slewa, and H. Kørner, “Lymph node harvest in colon cancer: influence of microsatellite instability and proximal tumor location,” World Journal of Surgery, vol. 33, no. 12, pp. 2695–2703, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. N. N. Baxter, D. J. Virnig, D. A. Rothenberger, A. M. Morris, J. Jessurun, and B. A. Virnig, “Lymph node evaluation in colorectal cancer patients: a population-based study,” Journal of the National Cancer Institute, vol. 97, no. 3, pp. 219–225, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. P. P. Tekkis, J. J. Smith, A. G. Heriot, A. W. Darzi, M. R. Thompson, and J. D. Stamatakis, “A national study on lymph node retrieval in resectional surgery for colorectal cancer,” Diseases of the Colon and Rectum, vol. 49, no. 11, pp. 1673–1683, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. L. Bui, E. Rempel, D. Reeson, and M. Simunovic, “Lymph node counts, rates of positive lymph nodes, and patient survival for colon cancer surgery in Ontario, Canada: a population-based study,” Journal of Surgical Oncology, vol. 93, no. 6, pp. 439–445, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. R. Ansari, M. Mahdavinia, A. Sadjadi et al., “Incidence and age distribution of colorectal cancer in Iran: results of a population-based cancer registry,” Cancer Letters, vol. 240, no. 1, pp. 143–147, 2006. View at Publisher · View at Google Scholar · View at Scopus