Table 1: Classification of antidesmoplastic agents.

AgentClass

PD 98059MEK 1 inhibitor
U0126MEK inhibitor
LY294002ERK inhibitor
PP1-PP2TβR inhibitors
SB431542 and SB525334TβRI selective inhibitor
LY2109761TβRI/II dual inhibitor
SD-208TβRI inhibitor
AP 12009 TGFβ2 mRNA phosphorothioate antisense oligodeoxynucleotide
2G8Neutralising antibody to TβR2 neutralising antibody
IPI-926SMO Semisynthetic cyclopamine analogue inhibitor
GDC-04492-arylpyridine class SMO inhibitor
iRGDDisulfide-based cyclic RGD tumour-penetrating peptide
CP870,893IgG2 antibody to CD40
AB0023Allosteric inhibitor of LOX-L2