Hyperthermic Intraperitoneal Chemotherapy with Melphalan: A Summary of Clinical and Pharmacological Data in 34 Patients

Table 2

Univariate analysis of clinical factors associated with grade 4 postoperative morbidity in 34 patients treated with cytoreductive surgery and HIPEC with melphalan.

Clinical variable	Grade 4 morbidity		𝑃 value
	Yes	No
Dose of melphalan			0.01
50 mg/m^2	0
60 mg/m^2	0
70 mg/m^2	4
Number of peritonectomies			<0.001
≤2	1
>2	5
Number of visceral resections			0.002
≤2	0
>2	6
Peritoneal cancer index			0.38
≤20	1
>20	5
EPIC			0.13
Yes	2
No	26