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Gastroenterology Research and Practice
Volume 2012 (2012), Article ID 897678, 9 pages
http://dx.doi.org/10.1155/2012/897678
Research Article

Nutrient Availability Alters the Effect of Autophagy on Sulindac Sulfide-Induced Colon Cancer Cell Apoptosis

1Research Division, Veterans Affairs Medical Center, 5901 E 7th Street, Long Beach, CA 90822, USA
2Department of Medicine, University of California, 101 The City Drive, Irvine, Orange, CA 92868, USA
3UCI Pathology Department, Chao Family Comprehensive Cancer Center, University of California, Irvine 92697, USA
4Neuro-Oncology Program, Chao Comprehensive Cancer Center, UC Irvine School of Medicine, University of California, Irvine, Orange, CA 92868, USA

Received 17 May 2012; Accepted 13 November 2012

Academic Editor: Akira Andoh

Copyright © 2012 Shiun-Kwei Chiou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Levine and G. Kroemer, “Autophagy in the pathogenesis of disease,” Cell, vol. 132, no. 1, pp. 27–42, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Pattingre, L. Espert, M. Biard-Piechaczyk, and P. Codogno, “Regulation of macroautophagy by mTOR and Beclin 1 complexes,” Biochimie, vol. 90, no. 2, pp. 313–323, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. I. Tanida, T. Ueno, and E. Kominami, “Human light chain 3/MAP1LC3B Is cleaved at its carboxyl-terminal Met 121 to expose Gly120 for lipidation and targeting to autophagosomal membranes,” Journal of Biological Chemistry, vol. 279, no. 46, pp. 47704–47710, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Kabeya, N. Mizushima, T. Ueno et al., “LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing,” The EMBO Journal, vol. 19, no. 21, pp. 5720–5728, 2000. View at Scopus
  5. Y. Ichimura, T. Kirisako, T. Takao et al., “A ubiquitin-like system mediates protein lipidation,” Nature, vol. 408, no. 6811, pp. 488–492, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Kuma, N. Mizushima, N. Ishihara, and Y. Ohsumi, “Formation of the ~350-kDa Apg12-Apg5·Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast,” Journal of Biological Chemistry, vol. 277, no. 21, pp. 18619–18625, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Abeliovich, W. A. Dunn, J. Kim, and D. J. Klionsky, “Dissection of autophagosome biogenesis into distinct nucleation and expansion steps,” Journal of Cell Biology, vol. 151, no. 5, pp. 1025–1033, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Bjørkøy, T. Lamark, A. Brech et al., “p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death,” Journal of Cell Biology, vol. 171, no. 4, pp. 603–614, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Debnath, E. H. Baehrecke, and G. Kroemer, “Does autophagy contribute to cell death?” Autophagy, vol. 1, no. 2, pp. 66–74, 2005. View at Scopus
  10. K. N. Dalby, I. Tekedereli, G. Lopez-Berestein, and B. Ozpolat, “Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer,” Autophagy, vol. 6, no. 3, pp. 322–329, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Thorburn, “Apoptosis and autophagy: regulatory connections between two supposedly different processes,” Apoptosis, vol. 13, no. 1, pp. 1–9, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. J. M. Gump and A. Thorburn, “Autophagy and apoptosis: what is the connection?” Trends in Cell Biology, vol. 21, no. 7, pp. 387–392, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Saiki, Y. Sasazawa, Y. Imamichi et al., “Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition,” Autophagy, vol. 7, no. 2, pp. 176–187, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Lépine, J. C. Allegood, Y. Edmonds, S. Milstien, and S. Spiegel, “Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage,” The Journal of Biological Chemistry, vol. 286, pp. 44380–44390, 2011.
  15. C. Bauvy, P. Gane, S. Arico, P. Codogno, and E. Ogier-Denis, “Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29,” Experimental Cell Research, vol. 268, no. 2, pp. 139–149, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. S. K. Chiou, N. Hoa, and A. Hodges, “Sulindac sulfide induces autophagic death in gastric epithelial cells via Survivin down-regulation: a mechanism of NSAIDs-induced gastric injury,” Biochemical Pharmacology, vol. 81, no. 11, pp. 1317–1323, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. S. K. Chiou and S. Mandayam, “NSAIDs enhance proteasomic degradation of survivin, a mechanism of gastric epithelial cell injury and apoptosis,” Biochemical Pharmacology, vol. 74, no. 10, pp. 1485–1495, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. M. W. Pfaffl, “A new mathematical model for relative quantification in real-time RT-PCR,” Nucleic Acids Research, vol. 29, no. 9, article e45, 2001. View at Scopus
  19. O. K. Mirzoeva, B. Hann, Y. K. Hom et al., “Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma,” Journal of Molecular Medicine, vol. 89, no. 9, pp. 877–889, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. G. E. Mortimore and A. R. Pösö, “Intracellular protein catabolism and its control during nutrient deprivation and supply,” Annual Review of Nutrition, vol. 7, pp. 539–564, 1987. View at Scopus
  21. A. Gupta, S. Roy, A. J. F. Lazar et al., “Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST),” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 32, pp. 14333–14338, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. R. K. Amaravadi, D. Yu, J. J. Lum et al., “Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma,” Journal of Clinical Investigation, vol. 117, no. 2, pp. 326–336, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Kroemer and B. Levine, “Autophagic cell death: the story of a misnomer,” Nature Reviews Molecular Cell Biology, vol. 9, no. 12, pp. 1004–1010, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Mandayam, R. Huang, A. S. Tarnawski, and S. K. Chiou, “Roles of survivin isoforms in the chemopreventive actions of NSAIDS on colon cancer cells,” Apoptosis, vol. 12, no. 6, pp. 1109–1116, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. T. K. Niu, Y. Cheng, X. Ren, and J. M. Yang, “Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis,” FEBS Letters, vol. 584, no. 16, pp. 3519–3524, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Kang, H. J. Zeh, M. T. Lotze, and D. Tang, “The Beclin 1 network regulates autophagy and apoptosis,” Cell Death and Differentiation, vol. 18, no. 4, pp. 571–580, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Zhang, J. Z. Fields, S. M. Ehrlich, and B. M. Boman, “The chemopreventive agent sulindac attenuates expression of the antiapoptotic protein survivin in colorectal carcinoma cells,” Journal of Pharmacology and Experimental Therapeutics, vol. 308, no. 2, pp. 434–437, 2004. View at Publisher · View at Google Scholar · View at Scopus