Table 1: Major phase III GEM-based combination chemotherapy.

RegimeNo. ptsORR (%)PFS/TTP (mo)OS (mo)Reference

GEM + cisplatin19510.25.37.5 Heinemann et al. [4]
GEM8.23.16.0
GEM + oxaliplatin832( )2.75.7Poplin et al. [5]
GEM2.64.9
GEM + 5FU3226.93.4*6.7Berlin et al. [7]
GEM5.62.25.4 * P = 0.022
GEM + capecitabine53319.25.37.1Cunningham et al. [9]
GEM12.43.86.2
GEM + capecitabine
GEM
319QoL samen/an/aBernhard et al. [10]
GEM + capecitabine31910.04.38.4 (10.1*)Herrmann et al. [11]
GEM7.83.97.2 (7.4)(*KPS 90–100; )

Abbreviation: ORR: overall response rate; PFS: progression free survival; TTP: time to progression; OS: overall survival; QoL: quality of life.