Table 2: Selected metaanalysis of GEM-based combination chemotherapy.

Reference No. of pts HR (all) HR for platinum HR for 5FU/capecitabine HR for other agents Heinemann et al. [12] 4465 0.91* 0.85 0.9 0.99 Sultana et al. [13] 9970 0.91 — — — Vaccaro et al. [14] 2422 0.87 0.94 (cisplatin, ) 0.86 () — 0.86 (oxaliplatin, )

*ECOG PS 0-1: HR 0.76, ; ECOG PS 2: HR 1.08, . Abbreviations: HR: hazard ratio; 5FU: fluorouracil.