Methylation and Expression of Retinoblastoma and Transforming Growth Factor-𝜷1 Genes in Epstein-Barr Virus-Associated and -Negative Gastric Carcinomas

Table 3

Correlation of methylation status of RB gene with clinicopathological data of gastric carcinoma patients.

	𝑛	Methylated (𝑛)	Unmethylated (𝑛)	χ ^2	𝑃
EBV infection
EBVaGC	30	24	6	6.490	0.011
EBVnGC	38	19	19
Age (yr)
<50	37	22	15	0.498	0.481
≥50	31	21	10
Gender
Male	58	36	22	—	0.835
Female	10	7	3
Pathologic grade
Poorly differentiated	60	40	20	—	0.216
Well-moderately differentiated	8	3	5
Location
Gastric cardia	14	10	4	3.172	0.205
Gastric body	28	20	8
Antrum	26	13	13
Depth of invasion
Invasion to serosa and invasion through serosa	46	33	13	4.423	0.036
Not invading serosa	22	10	12
Lymph node metastasis
Positive	38	29	9	6.339	0.012
Negative	30	14	16