Research Article
Methylation and Expression of Retinoblastoma and Transforming Growth Factor-1 Genes in Epstein-Barr Virus-Associated and -Negative Gastric Carcinomas
Table 6
Correlation of expression of RB and TGF-β1 protein with clinicopathological data of gastric carcinoma patients.
| | | RB | TGF-β1 | Expression () | Absent () | χ
2 | | Expression () | Absent () | χ
2 | |
| Age (yr) | | | | | | | | | | <50 | 37 | 21 | 16 | 0.180 | 0.671 | 20 | 17 | 1.320 | 0.251 | ≥50 | 31 | 16 | 15 | 21 | 10 | Gender | | | | | | | | | | Male | 58 | 31 | 27 | — | 0.972 | 35 | 23 | — | 0.742 | Female | 10 | 6 | 4 | 6 | 4 | Pathologic grade | | | | | | | | | | Poorly differentiated | 60 | 31 | 29 | — | 0.428 | 38 | 22 | — | 0.295 | Well-moderately differentiated | 8 | 6 | 2 | 3 | 5 | Location | | | | | | | | | | Gastric cardia | 14 | 7 | 7 | 2.091 | 0.352 | 8 | 6 | 0.318 | 0.853 | Gastric body | 28 | 13 | 15 | 18 | 10 | Antrum | 26 | 17 | 9 | 15 | 11 | Depth of invasion | | | | | | | | | | Invasion to serosa and invasion through serosa | 46 | 21 | 25 | 4.398 | 0.036 | 32 | 14 | 5.105 | 0.024 | Not invading serosa | 22 | 16 | 6 | 9 | 13 | Lymph node metastasis | | | | | | | | | | Positive | 38 | 16 | 22 | 5.259 | 0.022 | 29 | 9 | 9.235 | 0.002 | Negative | 30 | 21 | 9 | 12 | 18 |
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