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Gastroenterology Research and Practice
Volume 2012 (2012), Article ID 941954, 5 pages
http://dx.doi.org/10.1155/2012/941954
Research Article

Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma: Relationship with Tumor Stage and Survival after Esophagectomy

1Programa de Pós-Graduação em Ciências Cirúrgicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), 90035003 Porto Alegre, RS, Brazil
2Faculdade de Medicina, Universidade de Passo Fundo, 99010080 Passo Fundo, RS, Brazil
3Serviço de Cirurgia Digestiva, Hospital de Clínicas de Porto Alegre, 90035003 Porto Alegre, RS, Brazil
4Programa de Pós-Graduação: Ciências em Gastroenterologia e Hepatologia, Faculdade de Medicina, UFRGS, 90035003 Porto Alegre, RS, Brazil

Received 29 March 2012; Accepted 10 May 2012

Academic Editor: Jin-Lian Chen

Copyright © 2012 Daniel Navarini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and Aims. Esophageal adenocarcinoma (EA) is an aggressive tumor with increasing incidence in occidental countries. Several prognostic biomarkers have been proposed, including epidermal growth factor receptor (EGFR). The aim of this study was to assess whether EGFR expression predicts EA staging and patient survival. Methods. In this historical cohort, consecutive patients with EA managed between 2000 and 2010 were considered eligible for the study. Surgical specimens of patients treated with transhiatal esophagectomy were evaluated to establish EGFR expression and tumor differentiation. Staging was classified according with tumor-node-metastasis (TNM) system. Survival was determined according to either medical register or patient’s family contact. Results. Thirty-seven patients who underwent esophagectomy without presurgical chemotherapy or radiotherapy were studied. EGFR expression was found in 16 patients (43%). EGFR expression was more frequent as higher was the TNM (I and I I = 0 % versus I I I = 4 7 % versus I V = 1 0 0 %; 𝑃 < 0 . 0 0 1 ). Average survival in months was significantly shorter in the group of patients with EGFR expression (10.5 versus 21.7; 𝑃 = 0 . 0 0 1 ). Conclusions. In patients with esophageal adenocarcinoma treated with transhiatal esophagectomy, EGFR expression was related to higher TNM staging and shorter survival. EGFR expression might be assumed as a prognostic marker for esophageal adenocarcinoma.