Disposition Kinetics of Taxanes in Peritoneal Dissemination

Table 2

The values of AUC of paclitaxel and docetaxel in plasma and ascitic fluid after an i.p. injection of Taxol and Taxotere into AH130 tumor-bearing rats [15].

	ka	AUCp	AUCa	Ratio of
	(hr^−1)	(mg*hr/L)	(mg*hr/L)	AUCa/AUCp
Paclitaxel	0.0424 ± 0.0011*	17.6 ± 5.8*	7,480 ± 255*	425
Docetaxel	0.325 ± 0.043	8.50 ± 3.27	1,300 ± 191	153

The value of AUC was calculated from 0 to 24 h after an i.p. administration of 40 mg/kg of each drug.
ka: the apparent first-order absorption rate constant from the peritoneal cavity.
Each value represents the mean ± SD of three rats.
*Significantly different from Taxotere at P < 0.01.