Table 2: The values of AUC of paclitaxel and docetaxel in plasma and ascitic fluid after an i.p. injection of Taxol and Taxotere into AH130 tumor-bearing rats [15].

kaAUCpAUCaRatio of
 (hr−1)(mg*hr/L)(mg*hr/L)AUCa/AUCp

Paclitaxel0.0424 ± 0.0011*17.6 ± 5.8*7,480 ± 255*425
Docetaxel0.325 ± 0.0438.50 ± 3.271,300 ± 191153

The value of AUC was calculated from 0 to 24 h after an i.p. administration of 40 mg/kg of each drug.
ka: the apparent first-order absorption rate constant from the peritoneal cavity.
Each value represents the mean ± SD of three rats.
*Significantly different from Taxotere at P < 0.01.