Disposition Kinetics of Taxanes in Peritoneal Dissemination

Table 3

Pharmacokinetic parameters of paclitaxel (PAC) and docetaxel (DOC) in plasma and ascitic fluid after an i.p. administration of drugs in crEL or PS-80 to nontumor rats [18].

	ka	AUCp	AUCa	Ratio of
	(hr^−1)	(mg*hr/L)	(mg*hr/L)	AUCp/AUCa
PAC in 4.2% crEL	0.019±0.0018 *	18.4±3.3 *	8,870 ± 790*	0.00207 ± 0.00029*
DOC in 1.5% PS-80	0.394±0.021	6.93±1.32	1,170 ± 120	0.00592 ± 0.00153
DOC in 4.2% crEL	0.165±0.004	8.59±1.23	3,520 ± 110	0.00244 ± 0.00026
DOC in 7.5% PS-80	0.130±0.005	11.4±1.1	3,130 ± 320	0.00364 ± 0.00026

The value of AUC was calculated from 0 to 24 h after an i.p. administration of 40 mg/kg of each drug.
ka: the apparent first-order absorption rate constant from the peritoneal cavity.
Each value represents the mean ± SD of three rats.
*Significantly different from DOC in 1.5% PS-80 at 𝑃<0.01.