Table 3: Pharmacokinetic parameters of paclitaxel (PAC) and docetaxel (DOC) in plasma and ascitic fluid after an i.p. administration of drugs in crEL or PS-80 to nontumor rats [18].

kaAUCpAUCaRatio of
 (hr−1)(mg*hr/L)(mg*hr/L)AUCp/AUCa

PAC in 4.2% crEL * * 8,870 ± 790*0.00207 ± 0.00029*
DOC in 1.5% PS-80    1,170 ± 120 0.00592 ± 0.00153
DOC in 4.2% crEL  3,520 ± 1100.00244 ± 0.00026
DOC in 7.5% PS-80 3,130 ± 3200.00364 ± 0.00026

The value of AUC was calculated from 0 to 24 h after an i.p. administration of 40 mg/kg of each drug.
ka: the apparent first-order absorption rate constant from the peritoneal cavity.
Each value represents the mean ± SD of three rats.
*Significantly different from DOC in 1.5% PS-80 at .