Review Article
Disposition Kinetics of Taxanes in Peritoneal Dissemination
Table 3
Pharmacokinetic parameters of paclitaxel (PAC) and docetaxel (DOC) in plasma and ascitic fluid after an i.p. administration of drugs in crEL or PS-80 to nontumor rats [18].
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The value of AUC was calculated from 0 to 24 h after an i.p. administration of 40 mg/kg of each drug. ka: the apparent first-order absorption rate constant from the peritoneal cavity. Each value represents the mean ± SD of three rats. *Significantly different from DOC in 1.5% PS-80 at . |