- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 101083, 8 pages
Regulation Effect of Zinc Fingers and Homeoboxes 2 on Alpha-Fetoprotein in Human Hepatocellular Carcinoma
1Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2Department of Pathology, Guangdong Hospital of Chinese Traditional Medicine, Guangzhou, China
Received 4 July 2012; Accepted 27 January 2013
Academic Editor: Spiros D. Ladas
Copyright © 2013 Shao Wei Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- S. M. Tilghman, “The structure and regulation of the α-fetoprotein and albumin genes,” Oxford Surveys on Eukaryotic Genes, vol. 2, pp. 160–206, 1985.
- M. Olsson, G. Lindahl, and E. Ruoslahti, “Genetic control of α fetoprotein synthesis in the mouse,” Journal of Experimental Medicine, vol. 145, no. 4, pp. 819–827, 1977.
- E. P. Blankenhorn, R. Duncan, K. Huppi, and M. Potter, “Chromosomal location of the regulator of mouse α-fetoprotein, Afr-1,” Genetics, vol. 119, no. 3, pp. 687–691, 1988.
- B. T. Spear, “Mouse α-fetoprotein gene 5′ regulatory elements are required for postnatal regulation by raf and Rif,” Molecular and Cellular Biology, vol. 14, no. 10, pp. 6497–6505, 1994.
- J. Vacher, S. A. Camper, R. Krumlauf, R. S. Compton, and S. M. Tilghman, “raf Regulates the postnatal repression of the mouse α-fetoprotein gene at the posttranscriptional level,” Molecular and Cellular Biology, vol. 12, no. 2, pp. 856–864, 1992.
- D. K. Peyton, M. C. Huang, M. A. Giglia, N. K. Hughes, and B. T. Spear, “The α-fetoprotein promoter is the target of Afr1-mediated postnatal repression,” Genomics, vol. 63, no. 2, pp. 173–180, 2000.
- S. Perincheri, R. W. C. Dingle, M. L. Peterson, and B. T. Spear, “Hereditary persistence of α-fetoprotein and H19 expression in liver of BALB/cJ mice is due to a retrovirus insertion in the Zhx2 gene,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 2, pp. 396–401, 2005.
- S. Hu, M. Zhang, Z. Lv, J. Bi, Y. Dong, and J. Wen, “Expression of zinc-fingers and homeoboxes 2 in hepatocellular carcinogenesis: a tissue microarray and clinicopathological analysis,” Neoplasma, vol. 54, no. 3, pp. 207–211, 2007.
- Z. Lv, M. Zhang, J. Bi, F. Xu, S. Hu, and J. Wen, “Promoter hypermethylation of a novel gene, ZHX2, in hepatocellular carcinoma,” The American Journal of Clinical Pathology, vol. 125, no. 5, pp. 740–746, 2006.
- H. Shen, F. Luan, H. Liu et al., “ZHX2 is a repressor of α-fetoprotein expression in human hepatoma cell lines,” Journal of Cellular and Molecular Medicine, vol. 12, no. 6B, pp. 2772–2780, 2008.
- S. Sinha, S. N. Maity, J. Lu, and B. de Crombrugghe, “Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 5, pp. 1624–1628, 1995.
- C. G. Kim and M. Sheffery, “Physical characterization of the purified CCAAT transcription factor, α-CP1,” The Journal of Biological Chemistry, vol. 265, no. 22, pp. 13362–13369, 1990.
- W. Bi, L. Wu, F. Coustry, B. de Crombrugghe, and S. N. Maity, “DNA binding specificity of the CCAAT-binding factor CBF/NF-Y,” The Journal of Biological Chemistry, vol. 272, no. 42, pp. 26562–26572, 1997.
- K. Matuoka and K. Y. Chen, “Transcriptional regulation of cellular ageing by the CCAAT box-binding factor CBF/NF-Y,” Ageing Research Reviews, vol. 1, no. 4, pp. 639–651, 2002.
- H. Kawata, K. Yamada, Z. Shou et al., “Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor,” Biochemical Journal, vol. 373, part 3, pp. 747–757, 2003.
- H. Kawata, K. Yamada, Z. Shou, T. Mizutani, and K. Miyamoto, “The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3,” Gene, vol. 323, no. 1-2, pp. 133–140, 2003.
- H. Wienk, I. Lammers, A. Hotze et al., “The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension,” Biochemistry, vol. 48, no. 21, pp. 4431–4439, 2009.
- S. Y. Peng, W. J. Chen, P. L. Lai, Y. M. Jeng, J. C. Sheu, and H. C. Hsu, “High α-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: significance of hepatitis virus infection, age, p53 and β-catenin mutations,” International Journal of Cancer, vol. 112, no. 1, pp. 44–50, 2004.
- F. Farinati, D. Marino, M. de Giorgio et al., “Diagnostic and prognostic role of α-fetoprotein in hepatocellular carcinoma: both or neither?” American Journal of Gastroenterology, vol. 101, no. 3, pp. 524–532, 2006.
- H. A. Edmondson and P. E. Steiner, “Primary carcinoma of the liver: a study of 100 cases among 48,900,” Cancer, vol. 7, no. 3, pp. 462–503, 1954.
- T. R. Brummelkamp, R. Bernards, and R. Agami, “A system for stable expression of short interfering RNAs in mammalian cells,” Science, vol. 296, no. 5567, pp. 550–553, 2002.
- K. Yamada, H. Ogata-Kawata, K. Matsuura et al., “ZHX2 and ZHX3 repress cancer markers in normal hepatocytes,” Frontiers in Bioscience, vol. 14, no. 10, pp. 3724–3732, 2009.
- S. K. Ogden, K. C. Lee, K. Wernke-Dollries, S. A. Stratton, B. Aronow, and M. C. Barton, “p53 targets chromatin structure alteration to repress α-fetoprotein gene expression,” The Journal of Biological Chemistry, vol. 276, no. 45, pp. 42057–42062, 2001.