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Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 124530, 13 pages
http://dx.doi.org/10.1155/2013/124530
Research Article

Lung and Intestine: A Specific Link in an Ulcerative Colitis Rat Model

1Department of Internal Medicine of TCM, Dongzhimen Hospital, Beijing University of Chinese Medicine, 5 Hai Yun Cang, Dongcheng District, Beijing 100700, China
2Department of Internal Medicine of TCM, The Third Hospital affiliated with Henan University of Traditional Chinese Medicine, 63 Dong Ming, Jinshui District, Zhengzhou, Henan 450008, China
3Department of Internal Medicine of TCM, Nantong Hospital, 41 Jianshe Road, Chongchuan District, Nantong, Jiangsu 226000, China
4Department of Basic Theory of TCM, School of Preclinical Medicine, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Road, Chaoyang District, Beijing 100029, China

Received 14 November 2012; Revised 2 March 2013; Accepted 2 March 2013

Academic Editor: Bjørn Moum

Copyright © 2013 Yuan Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. To investigate the link and mechanisms between intestine and lung in the ulcerative colitis (UC) rat model. Materials and Methods. We used the UC rat model by immunological sensitization combined with local 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) in 50% ethanol enema, observed dynamically animal general state and body weight, examined the histological and functional changes in the colon, lung, liver, and kidney tissues, and detected microvascular endothelium response towards inflammation characterized with the expression of iNOS, TXB2, P-selectin, ICAM-1, and vascular endothelial growth factor A (VEGF-A) in the colon and lung tissue. Results. Pulmonary function results suggested ventilator disorder, and pathological findings showed interstitial pneumonia. There were no significant changes in the liver and kidney function and histopathology. The colon and lung tissue iNOS, TXB2, P-selectin, ICAM-1, and VEGF-A expression of the model rats was significantly higher than the normal rats at both time points. Conclusions. Our study is the first to demonstrate the close association between the large intestine and lung in the immune-TNBS-ethanol-induced UC rat model. Different organs and tissues with the same embryonic origin may share the same pathological specificities in a disease. The present study provided a new way of thinking for pathological changes in clinical complex diseases manifested with multiorgan damage.