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Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 201810, 6 pages
Serum Prohepcidin Levels Are Lower in Patients with Atrophic Gastritis
1Department of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu 480717, Republic of Korea
2MOT Cluster, Korea University of Technology and Education, Cheonan 330708, Republic of Korea
Received 29 November 2012; Revised 1 February 2013; Accepted 1 February 2013
Academic Editor: Vikram Kate
Copyright © 2013 Hyung-Keun Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- C. H. Park, E. V. Valore, A. J. Waring, and T. Ganz, “Hepcidin, a urinary antimicrobial peptide synthesized in the liver,” Journal of Biological Chemistry, vol. 276, no. 11, pp. 7806–7810, 2001.
- A. Krause, S. Neitz, H. Mägert et al., “LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity,” FEBS Letters, vol. 480, no. 2-3, pp. 147–150, 2000.
- Kulaksiz, Gehrke, Janetzko et al., “Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia,” Gut, vol. 53, no. 5, pp. 735–743, 2004.
- E. Nemeth, E. V. Valore, M. Territo, G. Schiller, A. Lichtenstein, and T. Ganz, “Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein,” Blood, vol. 101, no. 7, pp. 2461–2463, 2003.
- E. Nemeth, M. S. Tuttle, J. Powelson et al., “Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization,” Science, vol. 306, no. 5704, pp. 2090–2093, 2004.
- C. Pigeon, G. Ilyin, B. Courselaud et al., “A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload,” Journal of Biological Chemistry, vol. 276, no. 11, pp. 7811–7819, 2001.
- E. Nemeth, S. Rivera, V. Gabayan et al., “IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin,” Journal of Clinical Investigation, vol. 113, no. 9, pp. 1271–1276, 2004.
- C. Hershko, A. Lahad, and D. Kereth, “Gastropathic sideropenia,” Best Practice and Research, vol. 18, no. 2, pp. 363–380, 2005.
- S. DuBois and D. J. Kearney, “Iron-deficiency anemia and Helicobacter pylori infection: a review of the evidence,” American Journal of Gastroenterology, vol. 100, no. 2, pp. 453–459, 2005.
- Y. H. Choe, J. E. Lee, and S. K. Kim, “Effect of Helicobacter pylori eradication on sideropenic refractory anaemia in adolescent girls with Helicobacter pylori infection,” Acta Paediatrica, International Journal of Paediatrics, vol. 89, no. 2, pp. 154–157, 2000.
- T. Sugiyama, M. Tsuchida, K. Yokota, M. Shimodan, and M. Asaka, “Improvement of long-standing iron-deficiency anemia in adults after eradication of Helicobacter pylori infection,” Internal Medicine, vol. 41, no. 6, pp. 491–494, 2002.
- D. Mahalanabis, M. A. Islam, S. Shaikh et al., “Haematological response to iron supplementation is reduced in children with asymptomatic Helicobacter pylori infection,” British Journal of Nutrition, vol. 94, no. 6, pp. 969–975, 2005.
- C. Ciacci, F. Sabbatini, R. Cavallaro, et al., “Helicobacter pylori impairs iron absorption in infected individuals,” Digestive and Liver Disease, vol. 36, no. 7, pp. 455–460, 2004.
- R. Pellicano and M. Rizzetto, “Is hepcidin the bridge linking Helicobacter pylori and anemia of chronic infection? A research proposal,” Panminerva Medica, vol. 46, no. 3, pp. 165–169, 2004.
- E. Beutler, “Hepcidin mimetics from microorganisms? A possible explanation for the effect of Helicobacter pylori on iron homeostasis,” Blood Cells, Molecules, and Diseases, vol. 38, no. 1, pp. 54–55, 2007.
- P. Schwarz, J. A. M. Kübler, P. Strnad et al., “Hepcidin is localised in gastric parietal cells, regulates acid secretion and is induced by Helicobacter pylori infection,” Gut, vol. 61, no. 2, pp. 193–201, 2012.
- Y. E. C. Taes, B. Wuyts, J. R. Boelaert, A. S. De Vriese, and J. R. Delanghe, “Prohepcidin accumulates in renal insufficiency,” Clinical Chemistry and Laboratory Medicine, vol. 42, no. 4, pp. 387–389, 2004.
- S. Hsu, C. Chiang, C. Chien, and K. Hung, “Plasma prohepcidin positively correlates with hematocrit in chronic hemodialysis patients,” Blood Purification, vol. 24, no. 3, pp. 311–316, 2006.
- K. Satoh, K. Kimura, Y. Taniguchi et al., “Distribution of inflammation and atrophy in the stomach of Helicobacter pylori-positive and -negative patients with chronic gastritis,” American Journal of Gastroenterology, vol. 91, no. 5, pp. 963–969, 1996.
- M. F. Dixon, R. M. Genta, J. H. Yardley et al., “Classification and grading of Gastritis: the updated Sydney system,” American Journal of Surgical Pathology, vol. 20, no. 10, pp. 1161–1181, 1996.
- T. Ganz and E. Nemeth, “Hepcidin and iron homeostasis,” Biochimica et Biophysica Acta, vol. 1823, no. 9, pp. 1434–1443, 2012.
- E. Kemna, H. Tjalsma, C. Laarakkers, E. Nemeth, H. Willems, and D. Swinkels, “Novel urine hepcidin assay by mass spectrometry,” Blood, vol. 106, no. 9, pp. 3268–3270, 2005.
- N. Tomosugi, H. Kawabata, R. Wakatabe et al., “Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System,” Blood, vol. 108, no. 4, pp. 1381–1387, 2006.
- E. H. Kemna, H. Tjalsma, V. N. Podust, and D. W. Swinkels, “Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications,” Clinical Chemistry, vol. 53, no. 4, pp. 620–628, 2007.
- A. T. Murphy, D. R. Witcher, P. Luan, and V. J. Wroblewski, “Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry,” Blood, vol. 110, no. 3, pp. 1048–1054, 2007.
- T. Ganz, G. Olbina, D. Girelli, E. Nemeth, and M. Westerman, “Immunoassay for human serum hepcidin,” Blood, vol. 112, no. 10, pp. 4292–4297, 2008.
- M. F. Young, R. P. Glahn, M. Ariza-Nieto et al., “Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young women,” American Journal of Clinical Nutrition, vol. 89, no. 2, pp. 533–538, 2009.
- K. B. Hadley, L. K. Johnson, and J. R. Hunt, “Iron absorption by healthy women is not associated with either serum or urinary prohepcidin,” American Journal of Clinical Nutrition, vol. 84, no. 1, pp. 150–155, 2006.
- M. A. Roe, C. Spinks, A. M. Heath et al., “Serum prohepcidin concentration: no association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant women,” British Journal of Nutrition, vol. 97, no. 3, pp. 544–549, 2007.
- E. Costa, D. W. Swinkels, C. M. Laarakkers et al., “Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in haemodialysis patients,” Acta Haematologica, vol. 122, no. 4, pp. 226–229, 2009.
- S. Lee, E. Y. Song, Y. M. Yun et al., “Serum prohepcidin levels in helicobacter pylori infected patients with iron deficiency anemia,” Korean Journal of Internal Medicine, vol. 25, no. 2, pp. 195–200, 2010.
- S. Cherian, D. A. Forbes, A. G. Cook et al., “An insight into the relationships between hepcidin, anemia, infections and inflammatory cytokines in pediatric refugees: a cross-sectional study,” PLoS ONE, vol. 3, no. 12, article e4030, 2008.
- J. Y. Yim, N. Kim, S. H. Choi et al., “Seroprevalence of Helicobacter pylori in South Korea,” Helicobacter, vol. 12, no. 4, pp. 333–340, 2007.
- N. Kim, Y. S. Park, S. Cho et al., “Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a korean population Without significant gastroduodenal disease,” Helicobacter, vol. 13, no. 4, pp. 245–255, 2008.
- M. J. Thomson, D. M. Pritchard, S. A. Boxall, et al., “Gastric Helicobacter infection induces iron deficiency in the INS-GAS mouse,” PLoS One, vol. 7, no. 11, article e50194, 2012.
- I. M. Samloff, G. N. Stemmermann, L. K. Heilbrun, and A. Nomura, “Elevated serum pepsinogen I and II levels differ as risk factors for duodenal ulcer and gastric ulcer,” Gastroenterology, vol. 90, no. 3, pp. 570–576, 1986.
- J. S. Ren, F. Kamangar, Y. L. Qiao, et al., “Serum pepsinogens and risk of gastric and oesophageal cancers in the general population nutrition intervention trial cohort,” Gut, vol. 58, no. 5, pp. 636–642, 2009.
- M. Leja, L. Kupcinskas, K. Funka et al., “The validity of a biomarker method for indirect detection of gastric mucosal atrophy versus standard histopathology,” Digestive Diseases and Sciences, vol. 54, no. 11, pp. 2377–2384, 2009.