Table 5: Relationship between LVD and other clinicopathological features.

Clinicopathological featuresTotal casesLVD (mean ± SD)P value

Age (ys)
 ≧606910.94 ± 8.270.261
 <60368.97 ± 8.79
Gender
 Male739.71 ± 8.250.314
 Female3211.52 ± 8.92
Tumor size
  ≧5 cm5811.05 ± 8.350.291
 <5479.29 ± 8.59
Tumor location
 Upper1711.62 ± 7.640.435
 Middle348.78 ± 8.41
 Lower5410.77 ± 8.75
Lauren’s classification
 Intestinal7010.21 ± 8.510.934
 Diffuse3510.36 ± 8.49
TNM stage
 I + II417.41 ± 9.080.008
 III + IV6412.09 ± 7.56
Vascular invasion
  (+)2613.92 ± 6.700.004
  (−)799.06 ± 8.67
Serosa invasion
 (+)3711.5 ± 7.820.257
 (−)689.59 ± 8.77
Lymphatic invasion
 (+)6612.83 ± 7.46<0.001
 (−)395.92 ± 8.37
Lymph node metastasis
 (+)7012.20 ± 7.870.001
 (−)356.39 ± 8.37
Lymph node metastatic ratio
  ≧20%5113.40 ± 7.63<0.001
  <20%547.30 ± 8.19
VEGF-C
 (+)5912.63 ± 7.410.001
 (−)467.23 ± 8.34
VEGFR-3
 (+)6813.11 ± 7.010.011
 (−)379.12 ± 8.13
CNTN-1
 (+)6112.80 ± 7.95<0.001
 (−)446.75 ± 7.96