Table 1: RCTs with rifaximin (1200 mg/day) in the treatment of hepatic encephalopathy.

AuthorsCountryYearRifaximi
( )
Control ( )Comparative agentDuration of treatmentOutcomes

Paik et al. [21]South Korea20053222Lactulose 90 mL/d7 dMental status, flapping tremors, NCT, blood ammonia, and HE index
Verhagen et al. [24]Italy2001912Lactulose 60 mL/d21 dAsterixis, EEG, blood ammonia
Festi et al. [25]Italy19933028Lactulose 45 mL/d15 dMental status, asterixis, cancellation test, Reitan test, EEG, and blood ammonia
Bucci and Palmieri [26]Italy19932020Lactulose 90 mL/d15 dMental status, asterixis, cancellation test, EEG, trail making test, PSE index, and blood ammonia
Massa et al. [27]Spain19935053Lactitol 60 g/d5–10 dHE grade, mental status, asterixis, NCT, EEG, PSE index, and blood ammonia
Mas et al. [28]Italy20031413Lactulose 90 g/d3 monthMental status, asterixis, NCT, and blood ammonia
Loguercio et al. [29]Italy20032020Lactulose 120 mL/d3 monthMental status, asterixis, cancellation test, Reitan test, EEG, and PSE severity
Fera et al. [30]South Korea19933925Lactulose 90 mL/d7 dBlood ammonia, mental status, flapping tremors, NCT, and HE index

NCT: number connection test, EEG: electroencephalogram, and PSE: portosystemic encephalopathy.