Review Article
Rifaximin versus Nonabsorbable Disaccharides for the Treatment of Hepatic Encephalopathy: A Meta-Analysis
Table 3
Meta-analysis of psychchometric outcomes between rifaximin and nonabsorbable disaccharides.
| Psychometric outcomes | Rifaximin | Control |
Mean difference IV, random, 95% CI | Mean | SD | Total | Mean | SD | Total |
| Mental status |
| Bucci and Palmieri 1993 [26] | 0.8 | 0.5 | 30 | 1.2 | 0.3 | 28 | −0.40 [−0.61, −0.19] | Loguercio et al. 2003 [29] | 0.42 | 0.67 | 14 | 0.9 | 0.74 | 13 | −0.48 [−1.01, 0.05] | Massa et al. 1993 [27] | 0.6 | 0.2 | 20 | 1.2 | 0.3 | 20 | −0.60 [−0.76, −0.44] | Paik et al. 2005 [21] | 0.5 | 0.7 | 32 | 0.3 | 0.4 | 22 | 0.2 [−0.09, 0.49] |
| Total (95% CI) | | | 96 | | | 83 | −0.32 [−0.67, 0.03] |
|
Heterogeneity: = 0.10; = 22.09; df = 3 ( < 0.0001); = 86% |
Test for overall effect: = 1.80 ( = 0.07) |
| Asterixis |
| Bucci and Palmieri 1993 [26] | 0.5 | 0.3 | 30 | 1.2 | 0.3 | 28 | −0.40 [−0.61, −0.19] | Mas et al. 2003 [28] | 0 | 0.5 | 50 | 0 | 0.5 | 53 | 0.00 [−0.19, 0.19] | Massa et al. 1993 [27] | 0.1 | 0.2 | 20 | 0.1 | 0.2 | 20 | 0.00 [−0.12, 0.12] | Paik et al. 2005 [21] | 0.3 | 0.7 | 32 | 0.4 | 0.6 | 22 | −0.10 [−0.45, 0.25] |
| Total (95% CI) | | | 132 | | | 123 | −0.12 [−0.31, 0.08] |
|
Heterogeneity: = 0.03; = 10.85; df = 3 ( = 0.01); = 72% |
Test for overall effect: = 1.19 ( = 0.23) |
| EEG |
| Bucci and Palmieri 1993 [26] | 0.4 | 0.2 | 30 | 0.6 | 0.3 | 28 | −0.20 [−0.33, −0.07] | Mas et al. 2003 [28] | 0.6 | 0.9 | 50 | 0.9 | 0.9 | 53 | −0.30 [−0.65, 0.05] |
| Total (95% CI) | | | 80 | | | 81 | −0.21 [−0.34, −0.09] |
|
Heterogeneity: = 0.00; = 0.28; df = 1 ( = 0.60); = 0% |
Test for overall effect: = 3.37 ( = 0.0007) |
| PSE sum |
| Mas et al. 2003 [28] | 4 | 0.1 | 50 | 6 | 2 | 53 | −2.00 [−2.54, −1.46] | Massa et al. 1993 [27] | 3 | 0.5 | 20 | 5.5 | 0.5 | 20 | −2.50 [−2.78, −1.82] |
| Total (95% CI) | | | 70 | | | 73 | −2.30 [−2.78, −1.82] |
|
Heterogeneity: = 0.07; = 2.48; df = 1 ( = 0.12); = 60% |
Test for overall effect: = 9.40 ( < 0.00001) |
|
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IV: inverse variance, EEG: electroencephalogram, and PSE: portosystemic encephalopathy.
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