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Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 258514, 12 pages
http://dx.doi.org/10.1155/2013/258514
Review Article

An Increasing Prominent Disease of Klebsiella pneumoniae Liver Abscess: Etiology, Diagnosis, and Treatment

Department of Gastroenterology, Zhongshan Hospital, Fudan University, Xuhui, Shanghai 200032, China

Received 3 May 2013; Accepted 15 July 2013

Academic Editor: Edoardo Giovanni Giannini

Copyright © 2013 Yun Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Li, Y. Fu, J. Y. Wang et al., “Early diagnosis and therapeutic choice of Klebsiella pneumoniae liver abscess,” Frontiers of Medicine in China, vol. 4, no. 3, pp. 308–316, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. L. K. Siu, C. Fung, F. Chang et al., “Molecular typing and virulence analysis of serotype K1 Klebsiella pneumoniae strains isolated from liver abscess patients and stool samples from noninfectious subjects in Hong Kong, Singapore, and Taiwan,” Journal of Clinical Microbiology, vol. 49, no. 11, pp. 3761–3765, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. D. R. Chung, H. Lee, M. H. Park et al., “Fecal carriage of serotype K1 Klebsiella pneumoniae ST23 strains closely related to liver abscess isolates in Koreans living in Korea,” European Journal of Clinical Microbiology and Infectious Diseases, vol. 31, no. 4, pp. 481–486, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. D. S. Chan, S. Archuleta, R. M. Llorin, D. C. Lye, and D. Fisher, “Standardized outpatient management of Klebsiella pneumoniae liver abscesses,” International Journal of Infectious Diseases, vol. 17, no. 3, pp. e185–e188, 2013. View at Publisher · View at Google Scholar
  5. H. Hagiya, Y. Kuroe, H. Nojima et al., “Emphysematous liver abscesses complicated by septic pulmonary emboli in patients with diabetes: two cases,” Internal Medicine, vol. 52, no. 1, pp. 141–145, 2013.
  6. J. Rahimian, T. Wilson, V. Oram, and R. S. Holzman, “Pyogenic liver abscess: recent trends in etiology and mortality,” Clinical Infectious Diseases, vol. 39, no. 11, pp. 1654–1659, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. E. R. Lederman and N. F. Crum, “Pyogenic liver abscess with a focus on Klebsiella pneumoniae as a primary pathogen: an emerging disease with unique clinical characteristics,” The American Journal of Gastroenterology, vol. 100, no. 2, pp. 322–331, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. P. Golia and M. Sadler, “Pyogenic liver abscess: Klebsiella as an emerging pathogen,” Emergency Radiology, vol. 13, no. 2, pp. 87–88, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Pastagia and V. Arumugam, “Klebsiella pneumoniae liver abscesses in a public hospital in Queens, New York,” Travel Medicine and Infectious Disease, vol. 6, no. 4, pp. 228–233, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. J. V. Pope, D. L. Teich, P. Clardy, and D. C. McGillicuddy, “Klebsiella pneumoniae liver abscess: an emerging problem in North America,” Journal of Emergency Medicine, vol. 41, no. 5, pp. e103–e105, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. D. D. Sachdev, M. T. Yin, J. D. Horowitz, S. K. Mukkamala, S. E. Lee, and A. J. Ratner, “Klebsiella pneumoniae K1 liver abscess and septic endophthalmitis in a U.S. resident,” Journal of Clinical Microbiology, vol. 51, no. 3, pp. 1049–1051, 2013. View at Publisher · View at Google Scholar
  12. X. Nassif, J. M. Fournier, J. Arondel, and P. J. Sansonetti, “Mucoid phenotype of Klebsiella pneumoniae is a plasmid-encoded virulence factor,” Infection and Immunity, vol. 57, no. 2, pp. 546–552, 1989. View at Scopus
  13. S. K. Sobirk, C. Struve, and S. G. Jacobsson, “Primary Klebsiella pneumoniae liver abscess with metastatic spread to lung and eye, a North-european case report of an emerging syndrome,” Open Microbiology Journal, vol. 4, pp. 5–7, 2010. View at Publisher · View at Google Scholar
  14. R. Moore, D. O. 'Shea, T. Geoghegan, P. W. Mallon, and G. Sheehan, “Community-acquired Klebsiella pneumoniae liver abscess: an emerging infection in Ireland and Europe,” Infection, vol. 41, no. 1, pp. 681–686, 2013. View at Publisher · View at Google Scholar
  15. C. P. Fung, F. Y. Chang, S. C. Lee et al., “A global emerging disease of Klebsiella pneumoniae liver abscess: Is serotype K1 an important factor for complicated endophthalmitis?” Gut, vol. 50, no. 3, pp. 420–424, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. J. H. Wang, Y. Liu, S. S. Lee et al., “Primary liver abscess due to Klebsiella pneumoniae in Taiwan,” Clinical Infectious Diseases, vol. 26, no. 6, pp. 1434–1438, 1998. View at Scopus
  17. S. C. Chang, C. T. Fang, P. R. Hsueh, Y. C. Chen, and K. T. Luh, “Klebsiella pneumoniae isolates causing liver abscess in Taiwan,” Diagnostic Microbiology and Infectious Disease, vol. 37, no. 4, pp. 279–284, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. C. T. Fang, S. Y. Lai, W. C. Yi, P. R. Hsueh, K. L. Liu, and S. C. Chang, “Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess,” Clinical Infectious Diseases, vol. 45, no. 3, pp. 284–293, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. F. C. Tsai, Y. T. Huang, L. Y. Chang, and J. T. Wang, “Pyogenic liver abscess as endemic disease, Taiwan,” Emerging Infectious Diseases, vol. 14, no. 10, pp. 1592–1600, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. C. P. Fung, Y. T. Lin, J. C. Lin et al., “Klebsiella pneumoniae in gastrointestinal tract and pyogenic liver abscess,” Emerging Infectious Diseases, vol. 18, no. 8, pp. 1322–1325, 2012.
  21. J. J. Keller, M. C. Tsai, C. C. Lin, Y. C. Lin, and H. C. Lin, “Risk of infections subsequent to pyogenic liver abscess: a nationwide population-based study,” Clinical Microbiology and Infection, vol. 19, no. 8, pp. 717–722, 2013. View at Publisher · View at Google Scholar
  22. Y. T. Lin, F. D. Wang, P. F. Wu, and C. P. Fung, “Klebsiella pneumoniae liver abscess in diabetic patients: association of glycemic control with the clinical characteristics,” BMC Infectious Diseases, vol. 13, no. 1, article 56, 2013.
  23. Y. Keynan, J. A. Karlowsky, T. Walus, and E. Rubinstein, “Pyogenic liver abscess caused by hypermucoviscous Klebsiella pneumoniae,” Scandinavian Journal of Infectious Diseases, vol. 39, no. 9, pp. 828–830, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. J. F. Turton, H. Englender, S. N. Gabriel, S. E. Turton, M. E. Kaufmann, and T. L. Pitt, “Genetically similar isolates of Klebsiella pneumoniae serotype K1 causing liver abscesses in three continents,” Journal of Medical Microbiology, vol. 56, no. 5, pp. 593–597, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. T. C. Y. Pang, T. Fung, J. Samra, T. J. Hugh, and R. C. Smith, “Pyogenic liver abscess: an audit of 10 years' experience,” World Journal of Gastroenterology, vol. 17, no. 12, pp. 1622–1630, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Vila, A. Cassata, H. Pagella et al., “Appearance of Klebsiella pneumoniae liver abscess syndrome in Argentina: case report and review of molecular mechanisms of pathogenesis,” Open Microbiology Journal, vol. 5, pp. 107–113, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. S. C. Chen, W. Wu, C. H. Yeh et al., “Comparison of Escherichia coli and Klebsiella pneumoniae liver abscesses,” The American Journal of the Medical Sciences, vol. 334, no. 2, pp. 97–105, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. H. J. Mischinger, H. Hauser, H. Rabl et al., “Pyogenic liver abscess: studies of therapy and analysis of risk factors,” World Journal of Surgery, vol. 18, no. 6, pp. 852–858, 1994. View at Publisher · View at Google Scholar · View at Scopus
  29. J. K. Kim, D. R. Chung, S. H. Wie, J. H. Yoo, and S. W. Park, “Risk factor analysis of invasive liver abscess caused by the K1 serotype Klebsiella pneumoniae,” European Journal of Clinical Microbiology and Infectious Diseases, vol. 28, no. 1, pp. 109–111, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. N. K. Lee, S. Kim, J. W. Lee et al., “CT differentiation of pyogenic liver abscesses caused by Klebsiella pneumoniae versus non-Klebsiella pneumoniae,” The British Journal of Radiology, vol. 84, no. 1002, pp. 518–525, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. S. C. Chen, C. C. Huang, S. J. Tsai et al., “Severity of disease as main predictor for mortality in patients with pyogenic liver abscess,” The American Journal of Surgery, vol. 198, no. 2, pp. 164–172, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Fierer, “Biofilm formation and Klebsiella pneumoniae liver abscess: true, true and unrelated?” Virulence, vol. 3, no. 3, pp. 241–242, 2012.
  33. W. K. Huang, J. W. Chang, L. C. See et al., “Higher rate of colorectal cancer among patients with pyogenic liver abscess with Klebsiella pneumoniae than those without: an 11-year follow-up study,” Colorectal Disease, vol. 14, no. 12, pp. e794–e801, 2012. View at Publisher · View at Google Scholar
  34. K. Morii, A. Kashihara, S. Miura et al., “Successful hepatectomy for intraperitoneal rupture of pyogenic liver abscess caused by Klebsiella pneumoniae,” Clinical Journal of Gastroenterology, vol. 5, no. 2, pp. 136–140, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. C. C. Yang, C. H. Yen, M. W. Ho, and J. H. Wang, “Comparison of pyogenic liver abscess caused by non-Klebsiella pneumoniae and Klebsiella pneumoniae,” Journal of Microbiology, Immunology and Infection, vol. 37, no. 3, pp. 176–184, 2004. View at Scopus
  36. S. Basu, “Klebsiella pneumoniae: an emerging pathogen of pyogenic liver abscess,” Oman Medical Journal, vol. 24, no. 2, pp. 131–133, 2009.
  37. J. J. Mezhir, Y. Fong, L. M. Jacks et al., “Current management of pyogenic liver abscess: surgery is now second-line treatment,” Journal of the American College of Surgeons, vol. 210, no. 6, pp. 975–983, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. S. T. Law and M. K. K. Li, “Is there any difference in pyogenic liver abscess caused by Streptococcus milleri and Klebsiella spp?: Retrospective analysis over a 10-year period in a regional hospital,” Journal of Microbiology, Immunology and Infection, vol. 46, no. 1, pp. 11–18, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. S. U. Shin, C. M. Park, Y. Lee, E. C. Kim, S. J. Kim, and J. M. Goo, “Clinical and radiological features of invasive Klebsiella pneumoniae liver abscess syndrome,” Acta Radiologica, vol. 54, no. 5, pp. 557–563, 2013. View at Publisher · View at Google Scholar
  40. J. Y. Hui, M. K. W. Yang, D. H. Y. Cho et al., “Pyogenic liver abscesses caused by Klebsiella pneumoniae: US appearance and aspiration findings,” Radiology, vol. 242, no. 3, pp. 769–776, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. H. S. Alsaif, S. K. Venkatesh, D. S. G. Chan, and S. Archuleta, “CT appearance of pyogenic liver abscesses caused by Klebsiella pneumoniae,” Radiology, vol. 260, no. 1, pp. 129–138, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. J. R. Anstey, T. N. Fazio, D. L. Gordon et al., “Community-acquired Klebsiella pneumoniae liver abscesses—an “emerging disease” in Australia,” Medical Journal of Australia, vol. 193, no. 9, pp. 543–545, 2010.
  43. Y. J. Su, Y. C. Lai, Y. C. Lin, and Y. H. Yeh, “Treatment and prognosis of pyogenic liver abscess,” International Journal of Emergency Medicine, vol. 3, no. 4, pp. 381–384, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. M. El-Shabrawi and F. Hassanin, “Pyogenic liver abscess,” in Textbook of Clinical Pediatrics, vol. 3, pp. 2109–2112, 2012.
  45. T. Tatsuta, T. Wada, D. Chinda et al., “A case of gas-forming liver abscess with diabetes mellitus,” Internal Medicine, vol. 50, no. 20, pp. 2329–2332, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. S. C. H. Yu, S. S. M. Ho, W. Y. Lau et al., “Treatment of pyogenic liver abscess: prospective randomized comparison of catheter drainage and needle aspiration,” Hepatology, vol. 39, no. 4, pp. 932–938, 2004. View at Publisher · View at Google Scholar · View at Scopus
  47. A. A. Malik, S. U. Bari, K. A. Rouf, and K. A. Wani, “Pyogenic liver abscess: changing patterns in approach,” World Journal of Gastrointestinal Surgery, vol. 2, no. 12, pp. 395–401, 2010.
  48. L. K. Siu, K. M. Yeh, J. C. Lin, C. P. Fung, and F. Y. Chang, “Klebsiella pneumoniae liver abscess: a new invasive syndrome,” The Lancet Infectious Diseases, vol. 12, no. 11, pp. 881–887, 2012. View at Publisher · View at Google Scholar
  49. Y. T. Lin, L. K. Siu, J. C. Lin et al., “Seroepidemiology of Klebsiella pneumoniae colonizing the intestinal tract of healthy Chinese and overseas Chinese adults in Asian countries,” BMC Microbiology, vol. 12, article 13, 2012. View at Publisher · View at Google Scholar · View at Scopus
  50. J. C. Lin, L. K. Siu, C. P. Fung et al., “Impaired phagocytosis of capsular serotypes K1 or K2 Klebsiella pneumoniae in type 2 diabetes mellitus patients with poor glycemic control,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 8, pp. 3084–3087, 2006. View at Publisher · View at Google Scholar · View at Scopus
  51. Y. S. Yang, L. K. Siu, K. M. Yeh et al., “Recurrent Klebsiella pneumoniae liver abscess: clinical and microbiological characteristics,” Journal of Clinical Microbiology, vol. 47, no. 10, pp. 3336–3339, 2009. View at Publisher · View at Google Scholar · View at Scopus
  52. W. L. Yu, W. C. Ko, K. C. Cheng, C. C. Lee, C. C. Lai, and Y. C. Chuang, “Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes,” Diagnostic Microbiology and Infectious Disease, vol. 62, no. 1, pp. 1–6, 2008. View at Publisher · View at Google Scholar · View at Scopus
  53. C. R. Hsu, T. L. Lin, Y. C. Chen, H. C. Chou, and J. T. Wang, “The role of Klebsiella pneumoniae rmpA in capsular polysaccharide synthesis and virulence revisited,” Microbiology, vol. 157, part 12, pp. 3446–3457, 2011. View at Publisher · View at Google Scholar · View at Scopus
  54. C. T. Fang, Y. P. Chuang, C. T. Shun, S. C. Chang, and J. T. Wang, “A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications,” Journal of Experimental Medicine, vol. 199, no. 5, pp. 697–705, 2004. View at Publisher · View at Google Scholar · View at Scopus
  55. X. Nassif and P. J. Sansonetti, “Correlation of the virulence of Klebsiella pneumoniae K1 and K2 with the presence of a plasmid encoding aerobactin,” Infection and Immunity, vol. 54, no. 3, pp. 603–608, 1986. View at Scopus
  56. L. C. Ma, C. Fang, C. Z. Lee, C. T. Shun, and J. T. Wang, “Genomic heterogeneity in Klebsiella pneumoniae strains is associated with primary pyogenic liver abscess and metastatic infection,” Journal of Infectious Diseases, vol. 192, no. 1, pp. 117–128, 2005. View at Publisher · View at Google Scholar · View at Scopus
  57. M. C. Wu, Y. C. Chen, T. L. Lin, P. F. Hsieh, and J. T. Wang, “Cellobiose-specific phosphotransferase system of Klebsiella pneumoniae and its importance in biofilm formation and virulence,” Infection and Immunity, vol. 80, no. 7, pp. 2464–2472, 2012. View at Publisher · View at Google Scholar
  58. H. C. Chou, C. Z. Lee, L. C. Ma, C. T. Fang, S. C. Chang, and J. T. Wang, “Isolation of a chromosomal region of Klebsiella pneumoniae associated with allantoin metabolism and liver infection,” Infection and Immunity, vol. 72, no. 7, pp. 3783–3792, 2004. View at Publisher · View at Google Scholar · View at Scopus
  59. M. Ukikusa, T. Inomoto, T. Kitai et al., “Pneumoperitoneum following the spontaneous rupture of a gas-containing pyogenic liver abscess: report of a case,” Surgery Today, vol. 31, no. 1, pp. 76–79, 2001. View at Publisher · View at Google Scholar · View at Scopus
  60. J. A. Alvarez Pérez, J. J. González, R. F. Baldonedo et al., “Clinical course, treatment, and multivariate analysis of risk factors for pyogenic liver abscess,” The American Journal of Surgery, vol. 181, no. 2, pp. 177–186, 2001. View at Publisher · View at Google Scholar
  61. D. L. Paterson, W. Ko, A. von Gottberg et al., “Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum β-lactamases,” Clinical Infectious Diseases, vol. 39, no. 1, pp. 31–37, 2004. View at Publisher · View at Google Scholar · View at Scopus
  62. S. S. Lee, Y. S. Chen, H. C. Tsai et al., “Predictors of septic metastatic infection and mortality among patients with Klebsiella pneumoniae liver abscess,” Clinical Infectious Diseases, vol. 47, no. 5, pp. 642–650, 2008. View at Publisher · View at Google Scholar · View at Scopus
  63. H. P. Cheng, L. K. Siu, and F. Y. Chang, “Extended-spectrum cephalosporin compared to cefazolin for treatment of Klebsiella pneumoniae-caused liver abscess,” Antimicrobial Agents and Chemotherapy, vol. 47, no. 7, pp. 2088–2092, 2003. View at Publisher · View at Google Scholar · View at Scopus
  64. M. L. Durand, “Endophthalmitis,” Clinical Microbiology and Infection, vol. 19, no. 3, pp. 227–234, 2013. View at Publisher · View at Google Scholar
  65. A. H. Kashani and D. Eliott, “The emergence of Klebsiella pneumoniae endogenous endophthalmitis in the USA basic and clinical advances,” Journal of Ophthalmic Inflammation and Infection, vol. 3, no. 1, article 28, 2013.
  66. J. Lee, C. E. Oh, E. H. Choi, and H. J. Lee, “The impact of the increased use of piperacillin/tazobactam on the selection of antibiotic resistance among invasive Escherichia coli and Klebsiella pneumoniae isolates,” International Journal of Infectious Diseases, vol. 17, no. 8, pp. e638–e643, 2013. View at Publisher · View at Google Scholar
  67. J. Lee, H. Pai, Y. K. Kim et al., “Control of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a children's hospital by changing antimicrobial agent usage policy,” Journal of Antimicrobial Chemotherapy, vol. 60, no. 3, pp. 629–637, 2007. View at Publisher · View at Google Scholar · View at Scopus
  68. L. T. Tian, K. Yao, X. Y. Zhang et al., “Liver abscesses in adult patients with and without diabetes mellitus: an analysis of the clinical characteristics, features of the causative pathogens, outcomes and predictors of fatality: a report based on a large population, retrospective study in China,” Clinical Microbiology and Infection, vol. 18, no. 9, pp. E314–E330, 2012. View at Publisher · View at Google Scholar
  69. G. Ferraioli, A. Garlaschelli, D. Zanaboni et al., “Percutaneous and surgical treatment of pyogenic liver abscesses: observation over a 21-year period in 148 patients,” Digestive and Liver Disease, vol. 40, no. 8, pp. 690–696, 2008. View at Publisher · View at Google Scholar · View at Scopus
  70. G. Porras-Ramirez, M. H. Hernandez-Herrera, and J. D. Porras-Hernandez, “Amebic hepatic abscess in children,” Journal of Pediatric Surgery, vol. 30, no. 5, pp. 662–664, 1995. View at Scopus
  71. W. W. Hope, D. V. Vrochides, W. L. Newcomb, W. W. Mayo-Smith, and D. A. Iannitti, “Optimal treatment of hepatic abscess,” American Surgeon, vol. 74, no. 2, pp. 178–182, 2008. View at Scopus
  72. A. Onder, M. Kapan, A. Boyuk et al., “Surgical management of pyogenic liver abscess,” European Review for Medical and Pharmacological Sciences, vol. 15, no. 10, pp. 1182–1186, 2011.
  73. F. C. Yeh, K. M. Yeh, L. K. Siu et al., “Increasing opsonizing and killing effect of serum from patients with recurrent K1 Klebsiella pneumoniae liver abscess,” Journal of Microbiology, Immunology and Infection, vol. 45, no. 2, pp. 141–146, 2012. View at Publisher · View at Google Scholar · View at Scopus