Table 1: Mutations associated with resistance to clarithromycin and fluoroquinolone.

Mutant strain Number of independent
mutations analysed
Mutant allelesa
DesignationAmino acid changeMIC (µg/mL)

245A123SMUT3 A2147G 256
245C123SMUT3 A2147G 32
247A223SMUT3
No gyr 87 WT
A2147G
N87K
256
247C1No gyr 87 WT N87K 8
249A1No gyr 87 WT N87K 32
249C1No gyr 87 WT N87K 16
252A2No gyr 87 WT
23SMUT3
N87K
A2147G
32
252C4No gyr 87 WT
gyr 91 WT
23SMUT2
23SMUT3
N87K
D91N
A2146C
A2147G
32
253C1No gyr 87 WT N87K 16
254A123SMUT3 A2147G 256
119A123SMUT3 A2147G 32
275A123SMUT3 A2147G 128
305A123SMUT3 A2147G 64
305C123SMUT3 A2147G 128
369A1No gyr 87 WT N87K 16
436C123SMUT3 A2147G 256
499C123SMUT3 A2147G 64

aDistinct mutation identified is given an allele name (designation), which represents a specific change at the nucleotide (nt) in a gene and a corresponding amino acid change in the gene product.