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Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 290634, 8 pages
http://dx.doi.org/10.1155/2013/290634
Review Article

Fluorescence-Guided Surgery and Fluorescence Laparoscopy for Gastrointestinal Cancers in Clinically-Relevant Mouse Models

1Department of Surgery, University of California, San Diego, CA, USA
2AntiCancer, Inc., San Diego, CA, USA
3Moores UCSD Cancer Center, 3855 Health Science Drive No. 0987, La Jolla, CA 92093-0987, USA

Received 7 July 2012; Accepted 7 November 2012

Academic Editor: Guido Schumacher

Copyright © 2013 Cristina A. Metildi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

There are many challenges that face surgeons when attempting curative resection for gastrointestinal cancers. The ability to properly delineate tumor margins for complete resection is of utmost importance in achieving cure and giving the patient the best chance of prolonged survival. Targeted tumor imaging techniques have gained significant interest in recent years to enable better identification of tumor lesions to improve diagnosis and treatment of cancer from preoperative staging modalities to optimizing the surgeon’s ability to visualize tumor margins at the initial operation. Using unique characteristics of the tumor to fluorescently label the tissue can delineate tumor margins from normal surrounding tissue, allowing improved precision of surgical resection. In this paper, different methods of fluorescently labeling native tumor are discussed as well as the development of fluorescence laparoscopy and the potential role for fluorescence-guided surgery in the treatment of gastrointestinal cancers.