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Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 302398, 7 pages
http://dx.doi.org/10.1155/2013/302398
Research Article

Age-Dependent Fecal Bacterial Correlation to Inflammatory Bowel Disease for Newly Diagnosed Untreated Children

1Hedmark University College, Hamar, Norway
2Department of Chemistry, Biotechnology and Food Science, Norwegian University for Life Sciences, Ås, Oslo, Norway
3Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway
4EpiGen Institute, Research Centre, Akershus University Hospital, Lørenskog, Norway
5Pediatric Department, Oslo University Hospital, Ullevål, Oslo, Norway
6EpiGen Institute, Akershus University Hospital, University of Oslo, Oslo, Norway
7Medical Clinic, Oslo University Hospital, Rikshospitalet, Norway

Received 9 February 2013; Accepted 1 April 2013

Academic Editor: Devendra Amre

Copyright © 2013 Felix Chinweije Nwosu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The knowledge about correlation patterns between the fecal microbiota and inflammatory bowel diseases (IBD)—comprising the two subforms Crohn's disease (CD) and ulcerative colitis (UC)—for newly diagnosed untreated children is limited. To address this knowledge gap, a selection of faecal specimens (CD, and UC, ) and non-IBD controls () children (age < 18 years) was analysed utilising bacterial small subunit (SSU) rRNA. We found, surprising age dependence for the fecal microbiota correlating to IBD. The most pronounced patterns were that E. coli was positively (, ) and Bacteroidetes, negatively (, ) correlated to age for CD patients. For UC, we found an apparent opposite age-related disease correlation for both Bacteroides and Escherichia. In addition, there was an overrepresentation of Haemophilus for the UC children. From our, results we propose a model where the aetiology of IBD is related to an on-going immunological development in children requiring different age-dependent bacterial stimuli. The impact of our findings could be a better age stratification for understanding and treating IBD in children.