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Gastroenterology Research and Practice
Volume 2013 (2013), Article ID 340851, 6 pages
http://dx.doi.org/10.1155/2013/340851
Review Article

Impact of Physical Activity on Cancer-Specific and Overall Survival of Patients with Colorectal Cancer

1Department of Medical Oncology, APHP, Avicenne Hospital, 125 route de Stalingrad, 125 rue de Stalingrad, 93009 Bobigny, France
2Department of Pharmacology, APHP, Avicenne Hospital, 125 route de Stalingrad, 125 rue de Stalingrad, 93009 Bobigny, France
3Department of Radiotherapy, APHP, Avicenne Hospital, 125 route de Stalingrad, 125 rue de Stalingrad, 93009 Bobigny, France

Received 9 June 2013; Accepted 25 July 2013

Academic Editor: Antoni Castells

Copyright © 2013 Gaetan Des Guetz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Physical activity (PA) reduces incidence of colorectal cancer (CRC). Its influence on cancer-specific (CSS) and overall survival (OS) is controversial. Methods. We performed a literature-based meta-analysis (MA) of observational studies, using keywords “colorectal cancer, physical activity, and survival” in PubMed and EMBASE. No dedicated MA was found in the Cochrane Library. References were cross-checked. Pre- and postdiagnosis PA levels were assessed by MET. Usually, “high” PA was higher than 17 MET hour/week. Hazard ratios (HRs) for OS and CSS were calculated, with their 95% confidence interval. We used more conservative adjusted HRs, since variables of adjustment were similar between studies. When higher PA was associated with improved survival, HRs for detrimental events were set to <1. We used EasyMA software and fixed effect model whenever possible. Results. Seven studies (8056 participants) were included, representing 3762 men and 4256 women, 5210 colon and 1745 rectum cancers. Mean age was 67 years. HR CSS for postdiagnosis PA (higher PA versus lower) was 0.61 (0.44–0.86). The corresponding HR OS was 0.62 (0.54–0.71). HR CSS for prediagnosis PA was 0.75 (0.62–0.91). The corresponding HR OS was 0.74 (0.62–0.89). Conclusion. Higher PA predicted a better CSS. Sustained PA should be advised for CRC. OS also improved (reduced cardiovascular risk).