Table 2: Univariate analysis contributing to OS and RFS for all cases ( ).

 
Variables
  n OSRFS
P valueaP valuea

Age ≥ 70 (yes/no)125/1080.0960.779
Gender (male/female)159/740.0700.445
HCC stages (I, II/III, and IV)163/70<0.001<0.001
Maximum tumor size ≥ 3.5 cm (yes/no)116/1170.0160.071
Tumor number (single/multiple)162/710.005<0.001
IFN therapy after surgery (yes/no)16/2170.0390.019
Body mass index ≥ 25 kg/m2 (yes/no)60/1730.8180.124
Diabetes mellitus (yes/no)64/1690.3110.994
ICGR 15 ≥ 13.5% (yes/no)115/1180.0380.402
Total bilirubin ≥ 0.8 mg/dL (yes/no)115/1180.1420.487
Serum albumin ≥ 3.8 g/dL (yes/no)128/105<0.0010.088
AST ≥ 60 IU/L (yes/no)110/1230.0900.042
ALT ≥ 50 IU/L (yes/no)113/1200.2610.014
Platelets ≥ 12 × 104/mm3 (yes/no)128/1050.0650.679
Prothrombin time ≥ 87% (yes/no)122/1110.2360.067
AFP ≥ 20 ng/mL (yes/no)122/111<0.0010.010
DCP ≥ 100 mAU/mL (yes/no)135/980.1440.031
Total cholesterol ≥ 160 IU/L (yes/no)109/1240.4760.575
Microscopic capsule (yes/no)185/480.6300.551
Microscopic capsule invasion (yes/no)140/930.2150.467
Microscopic vascular invasion (yes/no)73/160<0.001<0.001
Microscopic surgical margin (yes/no)30/2030.6420.112

OS: overall survival, RFS: recurrence-free survival, HCC: hepatocellular carcinoma, IFN: interferon, ICGR 15: indocyanine green retention at 15 min, AST: aspartate aminotransferase, ALT: alanine aminotransferase, AFP: alpha-fetoprotein, DCP: des-γ-carboxy prothrombin, and alog-rank test.