Table 3: Multivariate analysis associated with OS after surgical resection for hepatocellular carcinoma.

VariableHazard ratio95% confidence intervalP valuea

HCC stage
Stage I or II1.0000.069
Stage III or IV0.423 0.168–1.070
Maximum tumor size
≥3.5 cm0.765 0.502–1.1670.214
<3.5 cm1.000
Tumor number
Single1.299 0.520–3.2440.576
Multiple1.000
IFN therapy after surgery
Yes3.0540.745–12.5200.121
No1.000
ICGR 15
≥13.5%0.9540.623–1.4600.828
<13.5%1.000
Serum albumin level
≥3.8 g/dL1.981 1.295–3.0310.002
<3.8 g/dL1.000
AFP level
≥20 ng/mL0.4250.274–0.660<0.001
<20 ng/mL1.000
Microscopic vascular invasion
Yes0.5490.359–0.8400.006
No1.000

OS: overall survival, HCC: hepatocellular carcinoma, IFN: interferon, ICGR 15: indocyanine green retention at 15 min, AFP: alpha-fetoprotein, and aThe Cox proportional hazard model.