Table 4: Multivariate analysis associated with RFS after surgical resection for hepatocellular carcinoma.

VariableHazard ratio95% confidence intervalP valuea

HCC stage
Stage I or II1.0000.766
Stage III or IV0.900 0.449–1.802
Tumor number
Single1.000 0.115
Multiple0.5730.287–1.144
IFN therapy after surgery
Yes2.7091.264–5.8070.010
No1.000
AST
≥60 IU/L1.0910.651–1.5950.933
<60 IU/L1.000
ALT
≥50 IU/L0.7700.489–1.2110.257
<50 IU/L1.000
AFP
≥20 ng/mL0.7390.522–1.0460.088
<20 ng/mL1.000
DCP
≥100 mAU/mL0.8460.612–1.1700.313
<100 mAU/mL1.000
Microscopic vascular invasion
Yes0.5600.397–0.7880.001
No1.000

RFS: recurrence-free survival, HCC: hepatocellular carcinoma, IFN: interferon, AST: aspartate aminotransferase, ALT: alanine aminotransferase, AFP: alpha-fetoprotein, DCP: des-γ-carboxy prothrombin, and aThe Cox proportional hazard model.