Table 1: Proposed categories of hereditary colorectal cancer syndromes for which genetic testing is possible.

Categories of hereditary colorectal cancer
FAPAFAPHNPCC/LynchJuvenile polyposisPeutz-JeghersCowden syndrome

Mean age at diagnosis of CRC32–3945–5542–49346420
No of polyps>10010–1001 (ie tumors)5–10 or  more jpTwo or more PJ polyps
Gene APC  
MYH
APC
MYH
MHS2, MLH1,
PMS1, PMS2
SMAD4
BMPR1A
STK11/LKBPTEN
Mode of inheritanceAD AD
AR
ADADAD

Adenomatous polyposis Coli.
Autosomal dominant.
Autosomal recessive.